Improvement in survival during the past 4 decades among patients with anterior skull base cancer Journal Article
| Authors: | Gil, Z.; Fliss, D. M.; Cavel, O.; Shah, J. P.; Kraus, D. H. |
| Article Title: | Improvement in survival during the past 4 decades among patients with anterior skull base cancer |
| Abstract: | Background The aims of this study were to determine the trends in survival of patients with anterior skull base cancer over several decades and to identify time-related changes in the demographic and clinical characteristics of this population. Methods In all, 282 patients who underwent craniofacial resection at Memorial Sloan-Kettering Cancer Center and Tel Aviv Medical Center were studied. Patients were categorized in accord with the period of surgery: early (1973-1984, n = 34), intermediate (1985-1996, n = 72), and later (1997-2008, n = 176). Results Patients operated after 1996 had higher rates of comorbidity, dural and pterygopalatine invasion, and multicompartmental involvement than those operated before 1996 (p ≤.001). There was a significant improvement in 5-year overall and disease-specific survival, from 55% and 57%, respectively, for patients operated before 1996, to 66% and 70%, respectively, for those operated after 1996 (p =.02 and p =.006, respectively). On multivariate analysis, surgery after 1996 was an independent predictor of outcome (HR, 0.39, p <.001). Conclusions The survival of patients with anterior skull base cancer is improving. Surgery after 1996 is an independent prognostic factor for an improved outcome. © 2011 Wiley Periodicals, Inc. |
| Keywords: | survival; squamous cell carcinoma; skull base; nasal cavity; craniofacial resection; sinuses; subcranial |
| Journal Title: | Head & Neck |
| Volume: | 34 |
| Issue: | 9 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2012-09-01 |
| Start Page: | 1212 |
| End Page: | 1217 |
| Language: | English |
| DOI: | 10.1002/hed.21886 |
| PROVIDER: | scopus |
| PUBMED: | 22076799 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2012" - "CODEN: HEANE" - "Source: Scopus" |
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