Improvement in survival of patients with oral cavity squamous cell carcinoma: An international collaborative study Journal Article
| Authors: | Amit, M.; Yen, T. C.; Liao, C. T.; Chaturvedi, P.; Agarwal, J. P.; Kowalski, L. P.; Ebrahimi, A.; Clark, J. R.; Kreppel, M.; Zöller, J.; Fridman, E.; Bolzoni, V. A.; Shah, J. P.; Binenbaum, Y.; Patel, S. G.; Gil, Z. |
| Article Title: | Improvement in survival of patients with oral cavity squamous cell carcinoma: An international collaborative study |
| Abstract: | BACKGROUND An association between the survival of patients with oral cavity squamous cell carcinoma (OCSCC) and advancements in diagnosis and therapy has not been established. METHODS This was a retrospective, longitudinal, international, population-based study of 2738 patients who underwent resection of OCSCC during 2 different decades. Characteristics of patients from 7 international cancer centers who received treatment between 1990 and 2000 (group A; n = 735) were compared with patients who received treatment between 2001 and 2011 (group B; n = 2003). RESULTS Patients in group B had more advanced tumors and tended to develop distant metastases more frequently than patients in group A (P =.005). More group B patients underwent selective neck dissection and received adjuvant radiotherapy (P <.001). Outcome analysis revealed a significant improvement in 5-year overall survival, from 59% for group A to 70% for group B (P <.001). There was also a significant improvement in disease-specific survival associated with operations performed before and after 2000 (from 69% to 81%, respectively; P <.001). Surgery after 2000, negative margins, adjuvant treatment, and early stage disease were independent predictors of a better outcome in multivariate analysis. The decade of treatment was an independent prognostic factor for cancer-specific mortality (hazard ratio, 0.42; 95% confidence interval, 0.3-0.6). CONCLUSIONS The survival rate of patients with OCSCC improved significantly during the past 2 decades despite older age, more advanced disease stage, and a higher rate of distant metastases. The current results suggest that the prognosis for patients with OCSCC has improved over time, presumably because of advances in imaging and therapy. |
| Keywords: | survival; time; margins; oral cavity; trends; squamous |
| Journal Title: | Cancer |
| Volume: | 119 |
| Issue: | 24 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2013-12-15 |
| Start Page: | 4242 |
| End Page: | 4248 |
| Language: | English |
| DOI: | 10.1002/cncr.28357 |
| PROVIDER: | scopus |
| PUBMED: | 24114787 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2014 -- CODEN: CANCA -- Source: Scopus |
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