Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study Journal Article

  

Authors:	Gil, Z.; Patel, S. G.; Cantu, G.; Fliss, D. M.; Kowalski, L. P.; Singh, B.; Snyderman, C.; Kraus, D. H.; Shah, J. P.; Bridger, P. G.; Cheesman, A. D.; Donald, P.; Gullane, P.; Janecka, I.; Kamata, S. E.; Levine, P. A.; Medina, L. R.; Pradhan, S.; Schramm, V.; Wei, W. I.
Article Title:	Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study
Abstract:	Background. The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. Methods. This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were ≤21 years old. Results. The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. Conclusion. Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population. © 2008 Wiley Periodicals, Inc.
Keywords:	osteosarcoma; adolescent; cancer survival; child; human tissue; treatment outcome; child, preschool; survival rate; young adult; major clinical study; overall survival; histopathology; squamous cell carcinoma; carcinoma, squamous cell; surgical flaps; multimodality cancer therapy; cancer adjuvant therapy; cancer radiotherapy; radiotherapy, adjuvant; follow up; glioma; follow-up studies; antineoplastic agent; cancer incidence; adenocarcinoma; tumor localization; melanoma; neoplasm recurrence, local; basal cell carcinoma; angiosarcoma; cancer mortality; childhood cancer; risk assessment; ewing sarcoma; sarcoma; postoperative complication; feasibility study; fibrosarcoma; surgical mortality; multivariate analysis; salivary gland neoplasms; safety; age distribution; skull base; skull base neoplasms; hemangiopericytoma; leiomyosarcoma; malignant fibrous histiocytoma; rhabdomyosarcoma; adenoid cystic carcinoma; children; transitional cell carcinoma; tumor classification; salivary gland carcinoma; craniofacial surgery; wound complication; cranial base; malignant tumors; pediatric tumors; sarcomas; chordoma; cranial nerve paralysis; eosinophilic granuloma; epithelioid sarcoma; esthesioneuroblastoma; skull cancer; tracheostomy; esthesioneuroblastoma, olfactory
Journal Title:	Head & Neck
Volume:	31
Issue:	3
ISSN:	1043-3074
Publisher:	John Wiley & Sons, Inc.
Date Published:	2009-03-01
Start Page:	308
End Page:	317
Language:	English
DOI:	10.1002/hed.20958
PUBMED:	19073003
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-62249202085&partnerID=40&md5=4e1a0af2ff8d6f6a3a3fbab96bec4ee0
Notes:	--- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: HEANE" - "Source: Scopus"

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