Results of anterior skull base surgery in pediatric and young adult patients Journal Article
| Authors: | Gross, N. D.; Ganly, I.; Patel, S. G.; Bilsky, M. H.; Shah, J. P.; Kraus, D. H. |
| Article Title: | Results of anterior skull base surgery in pediatric and young adult patients |
| Abstract: | We sought to better define the results of anterior skull base surgery in pediatric and young adult patients. We performed a single-institution, retrospective cohort study in a tertiary-care academic cancer center. Between 1973 and 2005, 234 patients underwent anterior skull base surgery at Memorial Sloan-Kettering Cancer Center. Of these, 19 patients were <21 years of age. Surgical indications, findings, and complications were reviewed. Survival outcomes were analyzed using the Kaplan-Meier method and compared with patients ≥21 years old. Nineteen patients <21 years old underwent a total of 20 procedures for lesions of the anterior skull base. Sarcoma was the most common indication for surgery including 6 (32%) patients treated for radiation-induced malignancies. Minor complications were noted with 6 (30%) procedures. There were no major complications and no perioperative deaths. The difference in 3-year recurrence-free (68% versus 59%; p=0.623) and overall survival (83% versus 66%; p=0.309) compared with patients ≥ 21 years old did not reach statistical significance. Anterior skull base surgery is well tolerated in pediatric and young adult patients <21 years of age. Survival is comparable to older patients treated similarly and appears strongly influenced by histology. |
| Keywords: | osteosarcoma; survival; adolescent; adult; cancer chemotherapy; child; controlled study; preschool child; school child; major clinical study; overall survival; cancer recurrence; adjuvant therapy; cancer radiotherapy; follow up; antineoplastic agent; treatment indication; adenocarcinoma; retrospective study; pediatric; sarcoma; cancer center; fibrosarcoma; neuroblastoma; complications; tertiary health care; malignant fibrous histiocytoma; spindle cell sarcoma; adenoid cystic carcinoma; diplopia; hematoma; wound dehiscence; liquorrhea; meningitis; pneumocephalus; esthesioneuroblastoma; cellulitis; skull surgery; craniofacial resection; skull base surgery; adult disease; childhood disease; lacrimal duct occlusion |
| Journal Title: | Skull Base |
| Volume: | 20 |
| ISSN: | 1531-5010 |
| Publisher: | Thieme Publishing |
| Date Published: | 2010-01-01 |
| Start Page: | 75 |
| End Page: | 81 |
| Language: | English |
| DOI: | 10.1055/s-0029-1238215 |
| PROVIDER: | scopus |
| PMCID: | PMC2853072 |
| PUBMED: | 20808531 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: SBKAB" - "Source: Scopus" |
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