New prognostic and predictive factors in advanced colorectal cancer Journal Article

Authors: Gil-Bazo, I.; Páramo, J. A.; García-Foncillas, J.
Article Title: New prognostic and predictive factors in advanced colorectal cancer
Abstract: Cancer patients often show a clinical tendency to thromboembolic events. This tendency is due to tumor cell-related factors together with the damage of the vascular endothelial exerted by chemotherapy treatment. Gastrointestinal tumors especially contribute to these types of events. More recently, the implication of tumor angiogenesis in clotting/fibrynolisys and plasminogen systems activation has been addressed in cancer patients. Finally, some hemostasis and angiogenesis-related factors such as platelets, von Willebrand factor, fibrinogen, plasminogen activator inhibitor type-1, D dimer, and vascular endotelial growth factor have been highlighted as new potential response and survival predictors in colorectal cancer patients. In this review article, the current evidence supporting the use of these proteins in assessing prognosis in colorectal cancer patients is critically exposed and discussed.
Keywords: survival; angiogenesis; antigen; vegf; hemostasis; factor; endothelial growth-factor; tumor-markers; cell-migration; clinical-applications; carcinoembryonic; von-willebrand-factor; plasminogen-activator inhibitor-1; colon-carcinoma; colorrectal cancer; d-dimer level
Journal Title: Medicina Clínica
Volume: 126
Issue: 14
ISSN: 0025-7753
Publisher: Elsevier Inc.  
Date Published: 2006-04-15
Start Page: 541
End Page: 548
Language: Spanish
ACCESSION: WOS:000237671500006
DOI: 10.1157/13087141
PUBMED: 16756907
Notes: --- - Review - "Source: Wos"
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