Prognostic markers other than hormone receptors in breast cancer Journal Article

  


Author: Fleisher, M.
Article Title: Prognostic markers other than hormone receptors in breast cancer
Abstract: Traditional prognostic markers are used to identify patients at risk of progressive breast cancer, thus enhancing subsequent monitoring and management. Over the past several years, many new prognostic factors based on the biochemical and molecular genetic characteristics of the cancer cell have been evaluated. These include the oncogene product c-erb B-2 protein, proteases (urokinase-type plasminogen activator) and its inhibitor plasminogen activator inhibitor-type 1, cathepsin D, tumor-suppressor genes such as p53, and epidermal growth factor receptor (EGFR). Prognostic factors are especially important in the identification of subsets of node-negative breast cancer patients who will have a recurrence within 5 years. This review examines some of the more extensively evaluated markers and points out discrepancies or lack of clinical concordance among the prognostic markers.
Keywords: human cell; molecular genetics; monitoring; breast cancer; cancer screening; tumor marker; cancer invasion; oncogene; prognostic factors; hormone receptor; cathepsin d; c-erb b-2; prognosis; human; article; oncogene c erb; breast cancer markers; cathepesin d; metastatic markers; proteases and inhibitors
Journal Title: Journal of Clinical Ligand Assay
Volume: 21
Issue: 1
ISSN: 1081-1672
Publisher: Clinical Ligand Assay Society  
Date Published: 1998-03-01
Start Page: 41
End Page: 46
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031925511&partnerID=40&md5=a6a274a0d432afc680a7ba32fd0b5d3f
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus