Proteolytic networks in cancer Journal Article
| Authors: | Mason, S. D.; Joyce, J. A. |
| Article Title: | Proteolytic networks in cancer |
| Abstract: | Proteases are important for multiple processes during malignant progression, including tumor angiogenesis, invasion and metastasis. Recent evidence reveals that tumor-promoting proteases function as part of an extensive multidirectional network of proteolytic interactions, in contrast to the unidirectional caspase cascade. These networks involve different constituents of the tumor microenvironment and key proteases, such as cathepsin B, urokinase-type plasminogen activator and several matrix metalloproteinases, occupy central nodes for amplifying proteolytic signals passing through the network. The proteolytic network interacts with other important signaling pathways in tumor biology, involving chemokines, cytokines, and kinases. Viewing these proteolytic interactions as a system of activating and inhibiting reactions provides insight into tumor biology and reveals relevant pharmaceutical targets. This review examines recent advances in understanding proteases in cancer and summarizes how the network of activity is co-opted to promote tumor progression. © 2010 Elsevier Ltd. |
| Keywords: | signal transduction; review; drug efficacy; nonhuman; solid tumor; bone metastasis; drug targeting; gemcitabine; pancreas cancer; antineoplastic agent; protein function; neoplasm; cell death; gene targeting; drug inhibition; apoptosis; bortezomib; proteasome inhibitor; multiple myeloma; protein degradation; gelatinase b; in vivo study; enzyme activity; caspase; proteomics; cancer research; cancer therapy; carcinogenesis; prostate cancer; scleroprotein; extracellular matrix; protein processing; protein synthesis; cancer cell; matrix metalloproteinase; cell migration; gene regulatory network; kaposi sarcoma; cathepsin b; proteinase; catalysis; tumor growth; proteinase inhibitor; protein cleavage; plasminogen activation; alteplase; urokinase; gelatinase a; tissue inhibitor of metalloproteinase; matrilysin; matrix metalloproteinase inhibitor; tumor microenvironment; clinical trial (topic); indinavir; cathepsin l; cathepsin k inhibitor; enzyme precursor; matrix metalloproteinase 14; nelfinavir; plasminogen; saquinavir |
| Journal Title: | Trends in Cell Biology |
| Volume: | 21 |
| Issue: | 4 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-04-01 |
| Start Page: | 228 |
| End Page: | 237 |
| Language: | English |
| DOI: | 10.1016/j.tcb.2010.12.002 |
| PROVIDER: | scopus |
| PUBMED: | 21232958 |
| PMCID: | PMC3840715 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: TCBIE" - "Source: Scopus" |
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