Cysteine cathepsin proteases as pharmacological targets in cancer Journal Article
| Authors: | Palermo, C.; Joyce, J. A. |
| Article Title: | Cysteine cathepsin proteases as pharmacological targets in cancer |
| Abstract: | Proteolytic activity is required for several key pro-tumorigenic processes: angiogenesis, invasion and metastasis. Consequently, increases in protease expression and activity are frequently reported in human cancers, and correlate with malignant progression and poor patient prognosis. Cysteine cathepsin proteases have recently emerged as an important class of proteolytic enzymes in cancer development, and cysteine cathepsin inhibitors have been proposed as anticancer agents. In this review, we highlight recent studies that now allow us to evaluate critically whether cysteine cathepsin inhibition represents a viable therapeutic strategy for the treatment of cancer. © 2007 Elsevier Ltd. All rights reserved. |
| Keywords: | protein expression; unclassified drug; clinical trial; drug activity; cancer growth; drug efficacy; nonhuman; antineoplastic agents; clinical trials as topic; bone metastasis; neoplasms; treatment indication; animals; metastasis; enzyme inhibition; breast cancer; protein degradation; enzyme activity; drug evaluation, preclinical; cysteine proteinase inhibitors; angiogenesis; psoriasis; carcinogenesis; drug delivery systems; cancer invasion; disease progression; rheumatoid arthritis; upregulation; osteoarthritis; cathepsin k; osteoporosis; cathepsin; cysteine proteinase inhibitor; cathepsins; up-regulation; disease models, animal; bone disease; bone defect; matrix metalloproteinase inhibitor; cathepsin s; cysteine proteinase; afg 495; balicatib; cra 013783; cra 028129; cysteine cathepsin protease; miv 701; mk 0822; n (3 propylcarbamoyloxirane 2 carbonyl)isoleucylproline; n [n (3 carboxyoxirane 2 carbonyl)leucyl]agmatine; ost 4077; relacatib; rwj 445380; sb 553484 |
| Journal Title: | Trends in Pharmacological Sciences |
| Volume: | 29 |
| Issue: | 1 |
| ISSN: | 0165-6147 |
| Publisher: | Cell Press |
| Date Published: | 2008-01-01 |
| Start Page: | 22 |
| End Page: | 28 |
| Language: | English |
| DOI: | 10.1016/j.tips.2007.10.011 |
| PUBMED: | 18037508 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 59" - "Export Date: 17 November 2011" - "CODEN: TPHSD" - "Source: Scopus" |
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