Factores ligados a angiogénesis, coagulación y fibrinólisis en el pronóstico de pacientes con cáncer colorectal Journal Article

  


Authors: Gil Bazo, I.; Catalán, V.; Páramo, J. A.; Sola, J. J.; Hernández Lizoáin, J. L.; García Foncillas, J.
Article Title: Factores ligados a angiogénesis, coagulación y fibrinólisis en el pronóstico de pacientes con cáncer colorectal
Abstract: Platelets involved in tumor angiogenesis are capable of secreting vascular endothelial growth factor (VEGF). On the other hand, plasminogen activator inhibitor-1 (PAI- 1) levels may regulate matrix degradation during tumor angiogenesis. Clotting-fibrinolytic system activation occurs during this process and is seen as an unfavourable clinical event. Von Willebrand factor (vWf), D-dimer (DD) and fibrinogen are sensitive markers of clotting and fibrinolysis. Platelet count and VEGF, PAI-1, vWf, DD and fibrinogen may predict clinical outcome in cancer patients. Our aim was to correlate VEGF, PAI-1, vWf, DD and fibrinogen levels in stage I to IV colorectal cancer (CRC) patients undergoing surgery and/or chemotherapy (CMT) with pathologic/immuno-histochemistry analysis in stage I to III patients and with response to treatment, and death risk in stage IV patients. 32 locally advanced and 32 metastatic CRC patients were enrolled. Blood samples were taken before surgery, and before and after fluoropyrimidine- based CMT. Stage IV patients received a median of 3 cycles of CMT (range: 2-10) between blood samples. In stage I to III patients, VEGF, platelets, fibrinogen and PAI-1 baseline levels correlated to tumor stage. Additionally, p21 and c-myc tumor expression was associated with higher vWf and lower DD levels, respectively. In metastatic patients, pre- and post-CMT VEGF, PAI-1 and CA 19.9 levels were related with progression rates. High VEGF and fibrinogen pre- and post- CMT concentrations correlated to a higher death risk. Copyrigth © Sociedad Iberoamericana de Información Científica (SIIC), 2009.
Keywords: angiogenesis; colorectal carcinoma; fibrinolysis; clotting; prognosis factors
Journal Title: Salud(i)Ciencia
Volume: 16
Issue: 8
ISSN: 1667-8982
Publisher: Sociedad Iberoamericana de Informacion Cientifica (S I I C)  
Date Published: 2009-07-01
Start Page: 848
End Page: 854
Language: Spanish
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84961364413&partnerID=40&md5=625318bd5a835dbc3a6755731d32912b
Notes: [Clotting, fibrinolysis and angiogenesis linked factors in the prognosis of colorectal carcinoma patients] -- Article -- Export Date: 4 April 2016 -- Source: Scopus