Novel approaches in allogeneic stem cell transplantation Journal Article
| Authors: | Papadopoulos, E. B.; Jakubowski, A. A. |
| Article Title: | Novel approaches in allogeneic stem cell transplantation |
| Abstract: | Allogeneic transplantation remains an integral part of the management of hematologic malignancies. However, transplant-related mortality, graft-versus-host disease, and disease recurrence continue to be major limitations to successful transplant outcomes and challenges to investigators in the field. Newer approaches have focused on reduction of the intensity of the conditioning regimens, harnessing the antitumor effects of the allograft, and development of adoptive immunotherapy strategies to circumvent the limitations. These developments provide physicians with the ability to tailor transplants to specific patients and their diseases. Copyright © 2006 by Current Science Inc. |
| Keywords: | cancer survival; treatment outcome; transplantation, homologous; unclassified drug; acute granulocytic leukemia; busulfan; fludarabine; allogeneic stem cell transplantation; clinical trial; review; cancer recurrence; cisplatin; clinical trials as topic; disease free survival; cytarabine; rituximab; cd34 antigen; cyclophosphamide; melphalan; herpes simplex; stem cell transplantation; antineoplastic activity; cancer mortality; thiotepa; monoclonal antibody; patient care; graft failure; hematologic malignancy; hla matching; myelodysplastic syndrome; nonhodgkin lymphoma; whole body radiation; hematologic neoplasms; cytotoxic t lymphocyte; graft versus host reaction; reduced intensity conditioning; natural killer cell; umbilical cord blood; cancer relapse; living donors; thymidine kinase; physician attitude; idarubicin; graft rejection; t cell depletion; donor selection; graft vs host disease; peripheral blood stem cell transplantation; cd34 selection; ganciclovir; adoptive immunotherapy; immunotherapy, adoptive; hla antigen; clinical trials; alemtuzumab; cell selection; thymocyte antibody; cladribine; individualization; nonmyeloablative stem cell transplantation; lymphocyte transfusion; minor histocompatibility antigen; nerve growth factor; monoclonal antibody t10b9 |
| Journal Title: | Current Oncology Reports |
| Volume: | 8 |
| Issue: | 5 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2006-09-01 |
| Start Page: | 325 |
| End Page: | 336 |
| Language: | English |
| DOI: | 10.1007/s11912-006-0054-0 |
| PUBMED: | 16901394 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 June 2012" - "CODEN: CORUA" - "Source: Scopus" |
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