Gut microbiota injury in allogeneic haematopoietic stem cell transplantation Journal Article

   


Authors: Shono, Y.; van den Brink, M. R. M.
Article Title: Gut microbiota injury in allogeneic haematopoietic stem cell transplantation
Abstract: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered to be the strongest curative immunotherapy for various malignancies (primarily, but not limited to, haematologic malignancies). However, application of allo-HSCT is limited owing to its life-threatening major complications, such as graft-versus-host disease (GVHD), relapse and infections. Recent advances in large-scale DNA sequencing technology have facilitated rapid identification of the microorganisms that make up the microbiota and evaluation of their interactions with host immunity in various diseases, including cancer. This has resulted in renewed interest regarding the role of the intestinal flora in patients with haematopoietic malignancies who have received an allo-HSCT and in whether the microbiota affects clinical outcomes, including GVHD, relapse, infections and transplant-related mortality. In this Review, we discuss the potential role of intestinal microbiota in these major complications after allo-HSCT, summarize clinical trials evaluating the microbiota in patients who have received allo-HSCT and discuss how further studies of the microbiota could inform the development of strategies that improve outcomes of allo-HSCT. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Keywords: antibiotic agent; antibiotic therapy; overall survival; review; nonhuman; infection; relapse; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; probiotic agent; intestine flora; homeostasis; infectious complication; clinical outcome; microbial diversity; prebiotic agent; human; priority journal; metabolome
Journal Title: Nature Reviews Cancer
Volume: 18
Issue: 5
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2018-05-01
Start Page: 283
End Page: 295
Language: English
DOI: 10.1038/nrc.2018.10
PROVIDER: scopus
PUBMED: 29449660
PMCID: PMC7485905
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045876811&doi=10.1038%2fnrc.2018.10&partnerID=40&md5=ee01e51f37bfc824b1796d14306407f0
Notes: Review -- Export Date: 1 June 2018 -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Yusuke Shono
    39 Shono
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