Novel biomarkers for outcome after allogeneic hematopoietic stem cell transplantation Review
| Authors: | Chen, S.; Zeiser, R. |
| Review Title: | Novel biomarkers for outcome after allogeneic hematopoietic stem cell transplantation |
| Abstract: | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a well-established curative treatment for various malignant hematological diseases. However, its clinical success is substantially limited by major complications including graft-vs.-host disease (GVHD) and relapse of the underlying disease. Although these complications are known to lead to significant morbidity and mortality, standardized pathways for risk stratification of patients undergoing allo-HSCT are lacking. Recent advances in the development of diagnostic and prognostic tools have allowed the identification of biomarkers in order to predict outcome after allo-HSCT. This review will provide a summary of clinically relevant biomarkers that have been studied to predict the development of acute GVHD, the responsiveness of affected patients to immunosuppressive treatment and the risk of non-relapse mortality. Furthermore, biomarkers associated with increased risk of relapse and subsequent mortality will be discussed. © Copyright © 2020 Chen and Zeiser. |
| Keywords: | gene mutation; overall survival; allogeneic stem cell transplantation; pathogenesis; review; liver transplantation; flow cytometry; sensitivity and specificity; biological marker; microrna; morbidity; interleukin 10; relapse; cell differentiation; proteomics; transcriptomics; risk factor; acute lymphoblastic leukemia; regulatory t lymphocyte; minimal residual disease; biomarker; cd4+ t lymphocyte; carcinogenicity; graft versus host reaction; cell migration; allogeneic hematopoietic stem cell transplantation; immunophenotyping; upregulation; intestine flora; gamma interferon inducible protein 10; immunosuppressive treatment; gvhd; tissue injury; life expectancy; neutrophil chemotaxis; tumor necrosis factor; rna sequence; nucleophosmin; metabolomics; clinical outcome; limit of detection; acute myeloid leukemia; lactobacillus; palmitic acid; cxcl11 chemokine; immune cells; inflammasome; human; droplet digital polymerase chain reaction; steroid-refractory graft-vs.-host disease; kidney injury molecule 1 |
| Journal Title: | Frontiers in Immunology |
| Volume: | 11 |
| ISSN: | 1664-3224 |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2020-08-18 |
| Start Page: | 1854 |
| Language: | English |
| DOI: | 10.3389/fimmu.2020.01854 |
| PROVIDER: | scopus |
| PUBMED: | 33013836 |
| PMCID: | PMC7461883 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 October 2020 -- Source: Scopus |
