The central nervous system is a target of acute graft versus host disease in mice Journal Article
| Authors: | Hartrampf, S.; Dudakov, J. A.; Johnson, L. K.; Smith, O. M.; Tsai, J.; Singer, N. V.; West, M. L.; Hanash, A. M.; Albert, M. H.; Liu, B.; Toth, M.; van den Brink, M. R. M. |
| Article Title: | The central nervous system is a target of acute graft versus host disease in mice |
| Abstract: | Despite significant advances in prevention and management, graft versus host disease (GVHD) is still a leading complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although skin, gut, liver, thymus, and lung are GVHD targets, neurological complications (NC) have also been reported following allo-HSCT. We demonstrate that the central nervous system (CNS) can be a direct target of alloreactive T cells following allo-HSCT in mice. We found significant infiltration of the CNS with donor T lymphocytes and cell death of neurons and neuroglia in allo-HSCT recipients with GVHD. We also found that allo-HSCT recipients with GVHD had deficits in spatial learning/memory and demonstrated increased anxious behavior. These findings highlight CNS sensitivity to damage caused by alloreactive donor T cells and represent the first characterization of target cell subsets and NC during GVHD. Therefore, these clinically relevant studies offer a novel and rational explanation for the well-described neurological symptoms observed after allo-HSCT. © 2013 by The American Society of Hematology. |
| Journal Title: | Blood |
| Volume: | 121 |
| Issue: | 10 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2013-03-07 |
| Start Page: | 1906 |
| End Page: | 1910 |
| Language: | English |
| PROVIDER: | scopus |
| PMCID: | PMC3591808 |
| PUBMED: | 23299314 |
| DOI: | 10.1182/blood-2012-09-456590 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - "CODEN: BLOOA" - ":doi 10.1182/blood-2012-09-456590" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work