The role of the intestinal microbiota in allogeneic HCT: Clinical associations and preclinical mechanisms Review

   


Authors: Nguyen, C. L.; Docampo, M. D.; van den Brink, M. R.; Markey, K. A.
Review Title: The role of the intestinal microbiota in allogeneic HCT: Clinical associations and preclinical mechanisms
Abstract: Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative-intent therapy for patients with hematological malignancies, but despite advances in the field in recent years, there is still a significant risk of post-transplant mortality. In addition to relapse of the underlying malignancy, the key contributors to this high mortality are graft-versus-host disease (GVHD) and infection. The intestinal microbiota is the collective term describing the community of bacteria, fungi, viruses and protozoa that resides in the human gastrointestinal tract. Bacterial communities have been studied most comprehensively, and disruption of these communities has been associated with the development of a variety of medical conditions in large clinical associative studies. Preclinical studies suggest a mechanistic role for the intestinal microbiota in the instruction and maintenance of both intestinal and systemic immune cell function. This review outlines our current understanding of the relationship between gut bacteria and allo-HCT outcomes, including infection, immune reconstitution, GVHD and relapse, drawing on evidence from both clinical associative studies and preclinical mechanistic studies. © 2020 Elsevier Ltd
Journal Title: Current Opinion in Genetics and Development
Volume: 66
ISSN: 0959-437X
Publisher: Elsevier Inc.  
Date Published: 2021-02-01
Start Page: 25
End Page: 35
Language: English
DOI: 10.1016/j.gde.2020.11.007
PROVIDER: scopus
PUBMED: 33388483
PMCID: PMC7969390
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098573140&doi=10.1016%2fj.gde.2020.11.007&partnerID=40&md5=47ec928027ff4240fea45eddf9208d2c
Notes: Review -- Export Date: 1 February 2021 -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Melissa Docampo
    25 Docampo
  3. Kate Ann Markey
    38 Markey
  4. Chi Nguyen
    17 Nguyen
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