An unconventional view of T cell reconstitution after allogeneic hematopoietic cell transplantation Review

   


Authors: Andrlová, H.; van den Brink, M. R. M.; Markey, K. A.
Review Title: An unconventional view of T cell reconstitution after allogeneic hematopoietic cell transplantation
Abstract: Allogeneic hematopoietic cell transplantation (allo-HCT) is performed as curative-intent therapy for hematologic malignancies and non-malignant hematologic, immunological and metabolic disorders, however, its broader implementation is limited by high rates of transplantation-related complications and a 2-year mortality that approaches 50%. Robust reconstitution of a functioning innate and adaptive immune system is a critical contributor to good long-term patient outcomes, primarily to prevent and overcome post-transplantation infectious complications and ensure adequate graft-versus-leukemia effects. There is increasing evidence that unconventional T cells may have an important immunomodulatory role after allo-HCT, which may be at least partially dependent on the post-transplantation intestinal microbiome. Here we discuss the role of immune reconstitution in allo-HCT outcome, focusing on unconventional T cells, specifically mucosal-associated invariant T (MAIT) cells, γδ (gd) T cells, and invariant NK T (iNKT) cells. We provide an overview of the mechanistic preclinical and associative clinical studies that have been performed. We also discuss the emerging role of the intestinal microbiome with regard to hematopoietic function and overall immune reconstitution. © Copyright © 2021 Andrlová, van den Brink and Markey.
Keywords: human tissue; human cell; review; nonhuman; allogeneic hematopoietic stem cell transplantation; intestine flora; natural killer t cell; immune reconstitution; allogeneic transplantation; gamma delta t lymphocyte; microbiome; preclinical study; human; mucosal-associated invariant t cell; invariant nk t (inkt) cells; mucosal invariant t cells (mait) cells; unconventional t cells; γδ t cells
Journal Title: Frontiers in Oncology
Volume: 10
ISSN: 2234-943X
Publisher: Frontiers Media S.A.  
Date Published: 2021-02-18
Start Page: 608923
Language: English
DOI: 10.3389/fonc.2020.608923
PROVIDER: scopus
PMCID: PMC7930482
PUBMED: 33680931
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102116323&doi=10.3389%2ffonc.2020.608923&partnerID=40&md5=c09c949077cd01cd962adb844b90c714
Notes: Review -- Export Date: 1 April 2021 -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Kate Ann Markey
    38 Markey
  3. Hana Andrlova
    11 Andrlova
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