ASBMT statement on routine prophylaxis for central nervous system recurrence of acute lymphoblastic leukemia following allogeneic hematopoietic cell transplantation Review

  

Authors:	Sauter, C. S.; DeFilipp, Z.; Inamoto, Y.; Johnston, L.; Nagler, A.; Savani, B. N.; Carpenter, P. A.; Perales, M. A.
Review Title:	ASBMT statement on routine prophylaxis for central nervous system recurrence of acute lymphoblastic leukemia following allogeneic hematopoietic cell transplantation
Abstract:	Hematologic malignancies treated with allogeneic hematopoietic cell transplantation (allo-HCT) have a variable incidence of post-transplantation central nervous system (CNS) relapse, with acute lymphoblastic leukemia (ALL) representing the most common disease histology. Although data supporting post-transplantation CNS prophylaxis for ALL in the pre-CNS penetrant systemic therapy era established this as standard practice, controversy exists regarding the role of post-transplantation CNS prophylaxis in the contemporary era. Here we review the most relevant (albeit exclusively retrospective) literature to date on the role of post-transplantation CNS prophylaxis in ALL. Given the paucity of data supporting the routine practice of post-transplantation CNS prophylaxis for ALL in the contemporary era, this position statement is anticipated to further stoke controversy and discussion within the transplantation community. Ultimately, only well-designed prospective clinical studies will elucidate the role of routine post-transplantation CNS prophylaxis. © 2019 American Society for Blood and Marrow Transplantation
Keywords:	cancer recurrence; editorial; practice guideline; cancer therapy; acute lymphoblastic leukemia; central nervous system; prophylaxis; allogeneic hematopoietic stem cell transplantation; induction chemotherapy; acute lymphoblastic lymphoma; central nervous system prophylaxis; human
Journal Title:	Biology of Blood and Marrow Transplantation
Volume:	25
Issue:	3
ISSN:	1083-8791
Publisher:	Elsevier Inc.
Date Published:	2019-03-01
Start Page:	e86
End Page:	e88
Language:	English
DOI:	10.1016/j.bbmt.2018.12.757
PUBMED:	30590125
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060510145&doi=10.1016%2fj.bbmt.2018.12.757&partnerID=40&md5=55104beb9056276a2e081179e5fc1afd
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/145744