CMV prevention strategies in allogeneic hematopoietic cell transplantation; the role of prophylaxis and pre-emptive monitoring in the era of letermovir Review
| Authors: | Yong, M. K.; Slavin, M. A.; Chemaly, R. F.; Papanicolaou, G. A. |
| Review Title: | CMV prevention strategies in allogeneic hematopoietic cell transplantation; the role of prophylaxis and pre-emptive monitoring in the era of letermovir |
| Abstract: | The preferred strategy for preventing CMV in at-risk populations in alloHCT has undergone a significant practice shift in recent years where the pendulum has swung from a pre-emptive approach to now offering letermovir prophylaxis to all CMV seropositive recipients. Letermovir prophylaxis has resulted in significant reductions in post-transplant clinically significant CMV infection (csCMVi) as well as other important outcomes such as CMV disease, resistant, and refractory CMV infections and nonrelapse mortality. However, prophylactic strategies are not without some limitations, namely delayed onset CMV infections, delayed CMV-specific T cell immune reconstitution, increased drug costs and limited data within pediatric populations. Thus, this review aims to provide an overview of prophylaxis and pre-emptive CMV preventative strategies, and how they are applicable in the current era of letermovir prophylaxis. © 2023 The Authors. Transplant Infectious Disease published by Wiley Periodicals LLC. |
| Keywords: | child; mortality; review; nonhuman; t lymphocyte; patient monitoring; hematopoietic stem cell transplantation; transplantation; health care quality; drug cost; prophylaxis; allogeneic hematopoietic stem cell transplantation; antivirus agent; high risk population; infection prevention; cytomegalovirus infection; cytomegalovirus; health care access; antiviral agents; immune reconstitution; procedures; cytomegalovirus infections; humans; human; preemptive antiviral therapy; letermovir; allogeneic haematopoietic cell transplantation |
| Journal Title: | Transplant Infectious Disease |
| Volume: | 25 |
| Issue: | Suppl. 1 |
| ISSN: | 1398-2273 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2023-11-01 |
| Start Page: | e14171 |
| Language: | English |
| DOI: | 10.1111/tid.14171 |
| PUBMED: | 37864299 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
