Intestinal microbiota and relapse after hematopoietic-cell transplantation Journal Article

Authors: Peled, J. U.; Devlin, S. M.; Staffas, A.; Lumish, M.; Khanin, R.; Littmann, E. R.; Ling, L. L.; Kosuri, S.; Maloy, M.; Slingerland, J. B.; Ahr, K. F.; Rodriguez, K. A. P.; Shono, Y.; Slingerland, A. E.; Docampo, M. D.; Sung, A. D.; Weber, D.; Alousi, A. M.; Gyurkocza, B.; Ponce, D. M.; Barker, J. N.; Perales, M. A.; Giralt, S. A.; Taur, Y.; Pamer, E. G.; Jenq, R. R.; Van Den Brink, M. R.
Article Title: Intestinal microbiota and relapse after hematopoietic-cell transplantation
Abstract: Purpose The major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora are associated with GVHD, bacteremia, and reduced overall survival after allo-HCT. Because intestinal bacteria are potent modulators of systemic immune responses, including antitumor effects, we hypothesized that components of the intestinal flora could be associated with relapse after allo-HCT. Methods The intestinal microbiota of 541 patients admitted for allo-HCT was profiled by means of 16S ribosomal sequencing of prospectively collected stool samples. We examined the relationship between abundance of microbiota species or groups of related species and relapse/progression of disease during 2 years of follow-up time after allo-HCT by using cause-specific proportional hazards in a retrospective discovery-validation cohort study. Results Higher abundance of a bacterial group composed mostly of Eubacterium limosum in the validation set was associated with a decreased risk of relapse/progression of disease (hazard ratio [HR], 0.82 per 10-fold increase in abundance; 95% CI, 0.71 to 0.95; P = .009). When the patients were categorized according to presence or absence of this bacterial group, presence also was associated with less relapse/progression of disease (HR, 0.52; 95% CI, 0.31 to 0.87; P = .01). The 2-year cumulative incidences of relapse/progression among patients with and without this group of bacteria were 19.8% and 33.8%, respectively. These associations remained significant in multivariable models and were strongest among recipients of T-cell–replete allografts. Conclusion We found associations between the abundance of a group of bacteria in the intestinal flora and relapse/progression of disease after allo-HCT. These might serve as potential biomarkers or therapeutic targets to prevent relapse and improve survival after allo-HCT. © 2017 by American Society of Clinical Oncology. All rights reserved.
Journal Title: Journal of Clinical Oncology
Volume: 35
Issue: 15
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2017-05-20
Start Page: 1650
End Page: 1659
Language: English
DOI: 10.1200/jco.2016.70.3348
PROVIDER: scopus
PMCID: PMC5455763
PUBMED: 28296584
Notes: Article -- Export Date: 2 August 2017 -- Source: Scopus
Citation Impact
MSK Authors
  1. Sergio Andres Giralt
    613 Giralt
  2. Eric Pamer
    265 Pamer
  3. Doris Ponce
    149 Ponce
  4. Miguel-Angel Perales
    456 Perales
  5. Juliet N Barker
    251 Barker
  6. Robert R Jenq
    103 Jenq
  7. Raya Khanin
    40 Khanin
  8. Ying Taur
    100 Taur
  9. Yusuke Shono
    36 Shono
  10. Molly Anna Maloy
    171 Maloy
  11. Sean McCarthy Devlin
    353 Devlin
  12. Lilan Ling
    40 Ling
  13. Jonathan U Peled
    61 Peled
  14. Melissa   Docampo
    17 Docampo
  15. Satyajit   Kosuri
    23 Kosuri
  16. Katya Frances Ahr
    4 Ahr
  17. Melissa Amy Lumish
    3 Lumish