Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT Journal Article

Authors: Haak, B. W.; Littmann, E. R.; Chaubard, J. L.; Pickard, A. J.; Fontana, E.; Adhi, F.; Gyaltshen, Y.; Ling, L.; Morjaria, S. M.; Peled, J. U.; van den Brink, M. R.; Geyer, A. I.; Cross, J. R.; Pamer, E. G.; Taur, Y.
Article Title: Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT
Abstract: Respiratory viral infections are frequent in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT) and can potentially progress to lower respiratory tract infection (LRTI). The intestinal microbiota contributes to resistance against viral and bacterial pathogens in the lung. However, whether intestinal microbiota composition and associated changes in microbe-derived metabolites contribute to the risk of LRTI following upper respiratory tract viral infection remains unexplored in the setting of allo-HCT. Fecal samples from 360 allo-HCT patients were collected at the time of stem cell engraftment and subjected to deep, 16S ribosomal RNA gene sequencing to determine microbiota composition, and short-chain fatty acid levels were determined in a nested subset of fecal samples. The development of respiratory viral infections and LRTI was determined for 180 days following allo-HCT. Clinical and microbiota risk factors for LRTI were subsequently evaluated using survival analysis. Respiratory viral infection occurred in 149 (41.4%) patients. Of those, 47 (31.5%) developed LRTI. Patients with higher abundances of butyrate-producing bacteria were fivefold less likely to develop viral LRTI, independent of other factors (adjusted hazard ratio 5 0.22, 95% confidence interval 0.04-0.69). Higher representation of butyrate-producing bacteria in the fecal microbiota is associated with increased resistance against respiratory viral infection with LRTI in allo-HCT patients. © 2018 by The American Society of Hematology.
Journal Title: Blood
Volume: 131
Issue: 26
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2018-06-28
Start Page: 2978
End Page: 2986
Language: English
DOI: 10.1182/blood-2018-01-828996
PROVIDER: scopus
PMCID: PMC6024637
PUBMED: 29674425
Notes: Article -- Export Date: 1 August 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Eric Pamer
    237 Pamer
  2. Justin Robert Cross
    46 Cross
  3. Ying Taur
    81 Taur
  4. Lilan Ling
    34 Ling
  5. Jonathan U Peled
    35 Peled
  6. Alexander Iosif Geyer
    17 Geyer
  7. Bastiaan Willem Haak
    1 Haak