Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study Journal Article
| Authors: | Lee, J. R.; Huang, J.; Magruder, M.; Zhang, L. T.; Gong, C.; Sholi, A. N.; Albakry, S.; Edusei, E.; Muthukumar, T.; Lubetzky, M.; Dadhania, D. M.; Taur, Y.; Pamer, E. G.; Suthanthiran, M. |
| Article Title: | Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study |
| Abstract: | Background: The gut microbiome is being associated increasingly with development of infections besides Clostridium difficile infection. A recent study found an association between butyrate-producing gut (BPG) bacteria and less frequent development of lower respiratory viral infections in allogeneic hematopoietic stem cell transplant recipients (Haak et al, Blood 131(26): 2978, 2018). In this investigation, we examine the relationship between the abundance of BPG bacteria and the development of viral infections in a cohort of kidney transplant recipients. Methods: We recruited 168 kidney transplant recipients who provided 510 fecal specimens in the first 3 months after transplantation and profiled the gut microbiota using 16S rRNA gene sequencing of the V4-V5 hypervariable region. We classified the kidney transplant recipients into higher BPG Bacteria Group and lower BPG Bacteria Group using the same criteria of 1% relative gut abundance of BPG bacteria as the Haak et al study. Results: Administration of antibiotics against anaerobes was associated with a significant decrease in the relative gut abundance of BPG bacteria. The higher BPG Bacteria Group was associated with less development of respiratory viral infections (Hazard Ratio [HR]: 0.28, P =.01) but not with less development of CMV viremia (HR: 0.38, P =.13) or BK viremia (HR: 1.02, P =.98) at 2 years post transplantation. Conclusion: Our pilot investigation supports future validation of the relationship between high relative gut abundance of BPG bacteria and decreased risk for development of respiratory viral infections. © 2019 Wiley Periodicals, Inc. |
| Keywords: | viral infections; gut microbiota; gut microbiome; butyrate; respiratory viral infections |
| Journal Title: | Transplant Infectious Disease |
| Volume: | 21 |
| Issue: | 6 |
| ISSN: | 1398-2273 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2019-12-01 |
| Start Page: | e13180 |
| Language: | English |
| DOI: | 10.1111/tid.13180 |
| PUBMED: | 31544324 |
| PROVIDER: | scopus |
| PMCID: | PMC6917841 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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