Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection Journal Article

   

Authors:	Magruder, M.; Sholi, A. N.; Gong, C.; Zhang, L.; Edusei, E.; Huang, J.; Albakry, S.; Satlin, M. J.; Westblade, L. F.; Crawford, C.; Dadhania, D. M.; Lubetzky, M.; Taur, Y.; Littman, E.; Ling, L.; Burnham, P.; De Vlaminck, I.; Pamer, E.; Suthanthiran, M.; Lee, J. R.
Article Title:	Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection
Abstract:	The origin of most bacterial infections in the urinary tract is often presumed to be the gut. Herein, we investigate the relationship between the gut microbiota and future development of bacteriuria and urinary tract infection (UTI). We perform gut microbial profiling using 16S rRNA gene deep sequencing on 510 fecal specimens from 168 kidney transplant recipients and metagenomic sequencing on a subset of fecal specimens and urine supernatant specimens. We report that a 1% relative gut abundance of Escherichia is an independent risk factor for Escherichia bacteriuria and UTI and a 1% relative gut abundance of Enterococcus is an independent risk factor for Enterococcus bacteriuria. Strain analysis establishes a close strain level alignment between species found in the gut and in the urine in the same subjects. Our results support a gut microbiota–UTI axis, suggesting that modulating the gut microbiota may be a potential novel strategy to prevent UTIs. © 2019, The Author(s).
Keywords:	gene sequence; major clinical study; clinical feature; genetic analysis; gene amplification; cohort analysis; bacteria (microorganisms); risk factor; rna; antibiotic resistance; sequence alignment; escherichia coli; urinary tract infection; bacteriuria; urinalysis; enterococcus; intestine flora; rna 16s; bioinformatics; antibiotic sensitivity; dna extraction; bacterium; feces analysis; fluorometry; kidney transplantation; enterococcus faecium; phylogeny; colony forming unit; cefazolin; kidney graft; klebsiella; urine culture; phylogenetic tree; excretion; digestive system; pathogen; escherichia; staphylococcus; enterococcus faecalis; infectivity; metagenomics; human; female; article; population abundance; uropathogen
Journal Title:	Nature Communications
Volume:	10
ISSN:	2041-1723
Publisher:	Nature Publishing Group
Date Published:	2019-12-04
Start Page:	5521
Language:	English
DOI:	10.1038/s41467-019-13467-w
PUBMED:	31797927
PROVIDER:	scopus
PMCID:	PMC6893017
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075969257&doi=10.1038%2fs41467-019-13467-w&partnerID=40&md5=24f12297321c31d63df67fdef9d99b2f
Notes:	Article -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/157620