Utility of routine pulmonary function test after autologous hematopoietic cell transplantation in lymphoma Journal Article
| Authors: | Dahi, P. B.; Kenny, S.; Flynn, J.; Devlin, S. M.; Ruiz, J. D.; Chinapen, S. A.; Lahoud, O. B.; Matasar, M. J.; Moskowitz, C. H.; Perales, M. A.; Shah, G.; Sauter, C. S.; Giralt, S. A.; Geyer, A. I.; Jakubowski, A. A. |
| Article Title: | Utility of routine pulmonary function test after autologous hematopoietic cell transplantation in lymphoma |
| Abstract: | This study aims to evaluate the predictive value of routine pulmonary function testing (PFT) at the 12-month mark post-autologous hematopoietic cell transplant (AHCT) in identifying clinically significant lung disease in lymphoma survivors. In 247 patients, 173 (70%) received BEAM (carmustine, etoposide, cytarabine, melphalan), and 49 (20%) received TBC (thiotepa, busulfan, cyclophosphamide) conditioning regimens. Abnormal baseline PFT was noted in 149 patients (60%). Thirty-four patients had a significant decline (reduction of >/= 20% in DLCO or FEV1 or FVC) in post-AHCT PFT, with the highest incidence in the CNS lymphoma group (39%). The incidence of clinically significant lung disease post-transplant was low at 2% and there was no association between abnormal pre- and 1-year post-transplant PFTs with the development of clinical lung disease. While this study illustrates the impact of treatment regimens on PFT changes, it did not demonstrate a predictive value of scheduled PFTs in identifying clinically significant post-AHCT lung disease. © 2023 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; controlled study; middle aged; major clinical study; busulfan; comparative study; primary central nervous system lymphoma; cytarabine; methotrexate; antineoplastic agent; cancer incidence; etoposide; lung disease; antineoplastic combined chemotherapy protocols; prevalence; cyclophosphamide; melphalan; practice guideline; hematopoietic stem cell transplantation; carmustine; thiotepa; hodgkin disease; cancer regression; lymphoma, non-hodgkin; lymphoma; transplantation conditioning; interstitial lung disease; forced expiratory volume; lung function test; transplantation, autologous; autologous hematopoietic stem cell transplantation; lymph node irradiation; non-hodgkin lymphoma; transplant; lung diseases; pulmonary hypertension; autotransplantation; organizing pneumonia; forced vital capacity; autologous; humans; human; male; female; article; pulmonary function test; pft |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 64 |
| Issue: | 14 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2023-01-01 |
| Start Page: | 2279 |
| End Page: | 2285 |
| Language: | English |
| DOI: | 10.1080/10428194.2023.2256912 |
| PUBMED: | 37690007 |
| PROVIDER: | scopus |
| PMCID: | PMC10981269 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Parastoo Dahi -- Source: Scopus |
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