Postchemotherapy histiocyte-rich pseudotumor involving the spleen Journal Article
| Authors: | Chandra, P.; Wen, Y. H.; Tuli, S.; Raphael, B. G.; Amorosi, E. L.; Medeiros, L. J.; Ibrahim, S. |
| Article Title: | Postchemotherapy histiocyte-rich pseudotumor involving the spleen |
| Abstract: | We report 2 cases of splenic postchemotherapy histiocyte-rich pseudotumor. Each patient had a history of diffuse large B-cell lymphoma, treated with multiagent chemotherapy. Computed tomography scans performed on both patients showed splenic masses. A positron emission tomography scan performed on 1 patient showed increased metabolic activity. The preoperative diagnosis in both patients was recurrent lymphoma, prompting splenectomy. The splenectomy specimens showed multiple, tan-white, firm nodules, up to 3.5 cm in diameter, that were histologically composed of central necrotic B cells (CD20+/CD3-), consistent with necrotic lymphoma, surrounded by numerous lipid-laden (xanthomatous) histiocytes. Clinical staging studies at the time of splenectomy showed no other sites of disease. We conclude that these histologic and immunophenotypic findings represent chemotherapy-induced tumor necrosis with a florid histiocytic reaction mimicking residual viable lymphoma. Others have used descriptive terminology or the term xanthomatous pseudotumor for these lesions that have been only rarely reported in the spleen previously. © American Society for Clinical Pathology. |
| Keywords: | human tissue; aged; human cell; prednisone; histopathology; splenectomy; cancer recurrence; case report; doxorubicin; cancer combination chemotherapy; cancer patient; rituximab; cancer staging; positron emission tomography; antineoplastic agent; tumor localization; carboplatin; computer assisted tomography; multiple cycle treatment; spleen; tumor volume; etoposide; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; stem cell transplantation; drug effect; pathology; necrosis; ifosfamide; b lymphocyte; b cell lymphoma; postchemotherapy; pseudotumor; xanthomatous histiocytes; histiocyte; large cell lymphoma; spleen pseudotumor; histiocytosis; lymphoma, large b-cell, diffuse |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 132 |
| Issue: | 3 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2009-09-01 |
| Start Page: | 342 |
| End Page: | 348 |
| Language: | English |
| DOI: | 10.1309/ajcpc67qogjxcezb |
| PUBMED: | 19687310 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: AJCPA" - "Source: Scopus" |
