Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor Journal Article
| Authors: | Shinoda, H.; Yoshida, A.; Teruya-Feldstein, J. |
| Article Title: | Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor |
| Abstract: | We describe a case of a 24-year-old man with a large anterior mediastinal mass showing a nonseminomatous germ cell tumor then subsequently developed hemophagocytic syndrome involving the bone marrow and liver. During the course of chemotherapy, he developed profound thrombocytopenia, eccymoses, and bleeding. He had moderate splenomegaly and splenectomy was performed to restore adequate hematologic reserve to permit further chemotherapy. The spleen showed marked erythrophagocytosis and markedly atypical histiocytes consistent with malignant histiocytoses. Atypical histiocytes stained positive for CD68, CD163, CD4, CD45 (LCA), and S-100. Cytogenetics studies were negative for i12p. The patient was refractory to therapy and ultimately died 5 months after diagnosis. © 2009 Lippincott Williams & Wilkins, Inc. |
| Keywords: | cancer chemotherapy; human tissue; osteolysis; human cell; splenectomy; case report; cisplatin; cancer combination chemotherapy; positron emission tomography; computer assisted tomography; infection; multiple cycle treatment; bone marrow; bone marrow suppression; spleen; etoposide; bleeding; thrombocytopenia; differential diagnosis; cytogenetics; dexamethasone; hemoglobin; necrosis; biopsy; ifosfamide; coughing; dizziness; liver; immunoglobulin g; bone marrow biopsy; laboratory test; splenomegaly; protein s 100; lactate dehydrogenase; thorax radiography; pancytopenia; neoplasms, germ cell and embryonal; weakness; histiocyte; cd4 antigen; antigens, cd; bone marrow transplantation; fatal outcome; germ cell tumor; mediastinal neoplasms; granulocyte colony stimulating factor; liver biopsy; fluorodeoxyglucose; cyclosporin; cd45 antigen; chorionic gonadotropin beta subunit; alpha fetoprotein; ecchymosis; hematology; s100 proteins; cd163 antigen; erythrophagocytosis; hemophagocytic syndrome; histiocytic sarcoma; mediastinal germ cell tumor; cd68 antigen; hepatosplenomegaly; malignant histiocytosis; mediastinum germ cell tumor; mediastinum germ celll tumor; rib fracture; histiocytes; lymphohistiocytosis, hemophagocytic |
| Journal Title: | Applied Immunohistochemistry & Molecular Morphology |
| Volume: | 17 |
| Issue: | 4 |
| ISSN: | 1541-2016 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-07-01 |
| Start Page: | 338 |
| End Page: | 344 |
| Language: | English |
| DOI: | 10.1097/PAI.0b013e3181897e8e |
| PUBMED: | 18987551 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: AIMMF" - "Source: Scopus" |
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