Splenectomy in recurrent epithelial ovarian cancer Journal Article
| Authors: | Gemignani, M. L.; Chi, D. S.; Gurin, C. C.; Curtin, J. P.; Barakat, R. R. |
| Article Title: | Splenectomy in recurrent epithelial ovarian cancer |
| Abstract: | Objective. To report a series of patients with recurrent epithelial ovarian cancer who underwent splenectomy for isolated parenchymal metastases. Methods. We performed a retrospective review of all patients who had a splenectomy for ovarian cancer at our institution during the period 1991 to 1997. Results. Six patients were identified who had a splenectomy performed for recurrent epithelial ovarian cancer confined to the splenic parenchyma. All had initial cytoreductive surgery for Stage III disease followed by platinum-based chemotherapy. Five patients underwent second-look surgery and four of them had pathologically confirmed persistent disease. All five patients who underwent second-look surgery had an intraperitoneal (ip) port placed and received platinum-based ip chemotherapy. Computed tomography (CT) scan performed during the posttreatment surveillance period demonstrated recurrent disease confined to the spleen in all six patients. Splenectomy was performed at a median of 57 months (range 28-88 months) after the initial surgery. The only major complication was a diaphragmatic tear necessitating chest tube placement. With a median follow-up of 25.5 months (range 6-65 months), all six patients are alive and free of disease. Conclusion. Splenectomy is a safe and feasible procedure in recurrent epithelial ovarian cancer. Isolated parenchymal splenic metastasis may occur as a late recurrence in epithelial ovarian cancer and splenectomy should be considered a pan of the management of this group of patients. |
| Keywords: | adult; cancer survival; clinical article; treatment outcome; aged; disease-free survival; middle aged; retrospective studies; splenectomy; cisplatin; paclitaxel; chemotherapy, adjuvant; cancer staging; recurrent cancer; ovarian neoplasms; carboplatin; metastasis; computer assisted tomography; ovary cancer; neoplasm recurrence, local; etoposide; tomography, x-ray computed; cyclophosphamide; postoperative complication; tube; mitoxantrone; reoperation; second look surgery; splenic neoplasms; medical records; intraperitoneal drug administration; humans; human; female; priority journal; article; diaphragm injury |
| Journal Title: | Gynecologic Oncology |
| Volume: | 72 |
| Issue: | 3 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1999-03-01 |
| Start Page: | 407 |
| End Page: | 410 |
| Language: | English |
| DOI: | 10.1006/gyno.1998.5141 |
| PUBMED: | 10053114 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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