Splenectomy in recurrent epithelial ovarian cancer Journal Article


Authors: Gemignani, M. L.; Chi, D. S.; Gurin, C. C.; Curtin, J. P.; Barakat, R. R.
Article Title: Splenectomy in recurrent epithelial ovarian cancer
Abstract: Objective. To report a series of patients with recurrent epithelial ovarian cancer who underwent splenectomy for isolated parenchymal metastases. Methods. We performed a retrospective review of all patients who had a splenectomy for ovarian cancer at our institution during the period 1991 to 1997. Results. Six patients were identified who had a splenectomy performed for recurrent epithelial ovarian cancer confined to the splenic parenchyma. All had initial cytoreductive surgery for Stage III disease followed by platinum-based chemotherapy. Five patients underwent second-look surgery and four of them had pathologically confirmed persistent disease. All five patients who underwent second-look surgery had an intraperitoneal (ip) port placed and received platinum-based ip chemotherapy. Computed tomography (CT) scan performed during the posttreatment surveillance period demonstrated recurrent disease confined to the spleen in all six patients. Splenectomy was performed at a median of 57 months (range 28-88 months) after the initial surgery. The only major complication was a diaphragmatic tear necessitating chest tube placement. With a median follow-up of 25.5 months (range 6-65 months), all six patients are alive and free of disease. Conclusion. Splenectomy is a safe and feasible procedure in recurrent epithelial ovarian cancer. Isolated parenchymal splenic metastasis may occur as a late recurrence in epithelial ovarian cancer and splenectomy should be considered a pan of the management of this group of patients.
Keywords: adult; cancer survival; clinical article; treatment outcome; aged; disease-free survival; middle aged; retrospective studies; splenectomy; cisplatin; paclitaxel; chemotherapy, adjuvant; cancer staging; recurrent cancer; ovarian neoplasms; carboplatin; metastasis; computer assisted tomography; ovary cancer; neoplasm recurrence, local; etoposide; tomography, x-ray computed; cyclophosphamide; postoperative complication; tube; mitoxantrone; reoperation; second look surgery; splenic neoplasms; medical records; intraperitoneal drug administration; humans; human; female; priority journal; article; diaphragm injury
Journal Title: Gynecologic Oncology
Volume: 72
Issue: 3
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 1999-03-01
Start Page: 407
End Page: 410
Language: English
DOI: 10.1006/gyno.1998.5141
PUBMED: 10053114
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Richard R Barakat
    629 Barakat
  2. Dennis S Chi
    707 Chi
  3. Mary L Gemignani
    218 Gemignani
  4. John P Curtin
    112 Curtin
  5. Cheryl Christine Gurin
    6 Gurin