Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception Journal Article
| Authors: | Mendoza, A.; Bou-Puerto, R.; Jara, J. S.; Dikiy, S.; Giovanelli, P.; Correa, D.; Manenti, S.; Andretta, E. S.; Dahia, C. L.; Rudensky, A. Y. |
| Article Title: | Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception |
| Abstract: | <p>The skin integrates diverse signals discerned by sensory neurons and immune cells to elicit adaptive responses to a range of stresses. Considering interactions between nervous and immune systems, we examined whether regulatory T (Treg) cells, which suppress systemic and local inflammation, can modulate activation of peripheral neurons. Acute Treg cell "loss of function" increased neuronal activation to noxious stimuli independently of their immunosuppressive function. This activity was mediated by a Treg cell subset capable of production of enkephalins encoded by the gene Penk, whose expression is facilitated by combined TCR and glucocorticoid receptor signaling. Punctual selective depletion of Penk-expressing Treg cells or specific ablation of Penk in Treg cells increased neuronal activation in response to noxious stimuli and associated inflammation. Our study indicates that a population of tissular Treg cells exhibits neuromodulatory activity to restrain local inflammation in the skin.</p> |
| Keywords: | brain; in-vivo; receptor; differentiation; glucocorticoids; identification; gene-expression; accumulation; sensory neurons; proenkephalin |
| Journal Title: | Science Immunology |
| Volume: | 10 |
| Issue: | 111 |
| ISSN: | 2470-9468 |
| Publisher: | Amer Assoc Advancement Science |
| Date Published: | 2025-09-05 |
| Start Page: | eadz6869 |
| Language: | English |
| ACCESSION: | WOS:001564596900001 |
| DOI: | 10.1126/sciimmunol.adz6869 |
| PROVIDER: | wos |
| PMCID: | PMC12478536 |
| PUBMED: | 40911697 |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Alexander Rudensky --Source: Wos |
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