CD49b defines functionally mature Treg cells that survey skin and vascular tissues Journal Article

   

Authors:	Fan, X.; Moltedo, B.; Mendoza, A.; Davydov, A. N.; Faire, M. B.; Mazutis, L.; Sharma, R.; Pe'er, D.; Chudakov, D. M.; Rudensky, A. Y.
Article Title:	CD49b defines functionally mature Treg cells that survey skin and vascular tissues
Abstract:	Regulatory T (Treg) cells prevent autoimmunity by limiting immune responses and inflammation in the secondary lymphoid organs and nonlymphoid tissues. While unique subsets of Treg cells have been described in some nonlymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. Furthermore, it is possible that Treg cells from similar tissue types share largely similar properties. We have identified a short-lived effector Treg cell subset that expresses the α2 integrin, CD49b, and exhibits a unique tissue distribution, being abundant in peripheral blood, vasculature, skin, and skin-draining lymph nodes, but uncommon in the intestines and in viscera-draining lymph nodes. CD49b+ Treg cells, which display superior functionality revealed by in vitro and in vivo assays, appear to develop after multiple rounds of cell division and TCR-dependent activation. Accordingly, single-cell RNA-seq analysis placed these cells at the apex of the Treg developmental trajectory. These results shed light on the identity and development of a functionally potent subset of mature effector Treg cells that recirculate through and survey peripheral tissues. © 2018 Fan et al.
Journal Title:	Journal of Experimental Medicine
Volume:	215
Issue:	11
ISSN:	0022-1007
Publisher:	Rockefeller University Press
Date Published:	2018-11-05
Start Page:	2796
End Page:	2814
Language:	English
DOI:	10.1084/jem.20181442
PUBMED:	30355617
PROVIDER:	scopus
PMCID:	PMC6219731
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056266469&doi=10.1084%2fjem.20181442&partnerID=40&md5=016b681ace7d33f935c8ae2300208e14
Notes:	Article -- Export Date: 3 December 2018 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/134811