Regulatory T cell ablation causes acute T cell lymphopenia Journal Article
| Authors: | Moltedo, B.; Hemmers, S.; Rudensky, A. Y. |
| Article Title: | Regulatory T cell ablation causes acute T cell lymphopenia |
| Abstract: | Regulatory T (Treg) cells enforce T cell homeostasis and maintain peripheral T cell tolerance. Here we report a previously unappreciated phenomenon of acute T cell lymphopenia in secondary lymphoid organs and non-lymphoid tissues triggered by Treg cell depletion that precedes the expansion of self-reactive T cells. Lymphopenia affects both neonates and adults indicating a dominant role of Treg cells in maintaining peripheral T cell numbers regardless of the developmental stage. The lymphopenia was neither triggered by caspase-dependent apoptosis nor macrophage-mediated clearance of T cells, nor diminished survival of naive or recently activated T cells due to paucity of IL-7. It is possible that transient lymphopenia associated with congenital or acute Treg cell deficiency may contribute to the development of T cell mediated autoimmune disorders. |
| Keywords: | mice; antigen; in-vivo; tolerance; mechanism; foxp3; autoimmune-disease; retinoic-acid; small-intestine; low avidity |
| Journal Title: | PLoS ONE |
| Volume: | 9 |
| Issue: | 1 |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Date Published: | 2014-01-01 |
| Start Page: | e86762 |
| Language: | English |
| ACCESSION: | WOS:000330288000139 |
| DOI: | 10.1371/journal.pone.0086762 |
| PROVIDER: | wos |
| PMCID: | PMC3900634 |
| PUBMED: | 24466225 |
| Notes: | Article -- e86762 -- Source: Wos |
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