Memory of inflammation in regulatory T cells Journal Article

Authors: van der Veeken, J.; Gonzalez, A. J.; Cho, H.; Arvey, A.; Hemmers, S.; Leslie, C. S.; Rudensky, A. Y.
Article Title: Memory of inflammation in regulatory T cells
Abstract: Eukaryotic cells can “remember” transient encounters with a wide range of stimuli, inducing lasting states of altered responsiveness. Regulatory T (Treg) cells are a specialized lineage of suppressive CD4 T cells that act as critical negative regulators of inflammation in various biological contexts. Treg cells exposed to inflammatory conditions acquire strongly enhanced suppressive function. Using inducible genetic tracing, we analyzed the long-term stability of activation-induced transcriptional, epigenomic, and functional changes in Treg cells. We found that the inflammation-experienced Treg cell population reversed many activation-induced changes and lost its enhanced suppressive function over time. The “memory-less” potentiation of Treg suppressor function may help avoid a state of generalized immunosuppression that could otherwise result from repeated activation. © 2016 Elsevier Inc.
Journal Title: Cell
Volume: 166
Issue: 4
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2016-08-11
Start Page: 977
End Page: 990
Language: English
DOI: 10.1016/j.cell.2016.07.006
PROVIDER: scopus
PMCID: PMC4996371
PUBMED: 27499023
Notes: Article -- Export Date: 1 September 2016 -- Source: Scopus
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MSK Authors
  1. Christina Leslie
    107 Leslie
  2. Saskia Hemmers
    12 Hemmers
  3. Aaron J. Arvey
    20 Arvey
  4. Hyunwoo   Cho
    3 Cho