Stability of the regulatory T cell lineage in vivo Journal Article
| Authors: | Rubtsov, Y. P.; Niec, R. E.; Josefowicz, S.; Li, L.; Darce, J.; Mathis, D.; Benoist, C.; Rudensky, A. Y. |
| Article Title: | Stability of the regulatory T cell lineage in vivo |
| Abstract: | Tissue maintenance and homeostasis can be achieved through the replacement of dying cells by differentiating precursors or self-renewal of terminally differentiated cells or relies heavily on cellular longevity in poorly regenerating tissues. Regulatory T cells (Treg cells) represent an actively dividing cell population with critical function in suppression of lethal immune-mediated inflammation. The plasticity of Treg cells has been actively debated because it could factor importantly in protective immunity or autoimmunity. By using inducible labeling and tracking of T reg cell fate in vivo, or transfers of highly purified T reg cells, we have demonstrated notable stability of this cell population under physiologic and inflammatory conditions. Our results suggest that self-renewal of mature Treg cells serves as a major mechanism of maintenance of the Treg cell lineage in adult mice. |
| Keywords: | controlled study; nonhuman; cell proliferation; forkhead transcription factors; mouse; animals; mice; mus; animal experiment; inflammation; cell renewal; in vivo study; cell population; cell lineage; mice, transgenic; regulatory t lymphocyte; cytokines; immune response; t-lymphocytes, regulatory; tamoxifen; longevity; autoimmunity; rodent; leukocyte count; immunity; gene knock-in techniques; homeostasis; lymphoid tissue; listeria monocytogenes; listeria infections; cell labeling; physiological response; regrowth |
| Journal Title: | Science |
| Volume: | 329 |
| Issue: | 5999 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2010-09-24 |
| Start Page: | 1667 |
| End Page: | 1671 |
| Language: | English |
| DOI: | 10.1126/science.1191996 |
| PUBMED: | 20929851 |
| PROVIDER: | scopus |
| PMCID: | PMC4262151 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 20 April 2011" - "CODEN: SCIEA" - "Source: Scopus" |
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