Dynamics of immune reconstitution and impact on outcomes across CAR-T cell products in large B-cell lymphoma Journal Article
| Authors: | Luan, D.; DeWolf, S.; Fei, T.; Raj, S.; Shah, G. L.; Lareau, C. A.; Alhomoud, M.; Salles, G.; Rivas-Delgado, A.; Rejeski, K.; Park, J. H.; Luttwak, E.; Luna de Abia, A.; Corona, M.; Ntrivalas, E.; Cassanello, G.; Gomez-Llobell, M.; Parascondola, A.; Scordo, M.; Hsu, K. C.; Palomba, M. L.; Perales, M. A.; Shouval, R. |
| Article Title: | Dynamics of immune reconstitution and impact on outcomes across CAR-T cell products in large B-cell lymphoma |
| Abstract: | SIGNIFICANCE: This study reveals differences in IR patterns after CAR-T therapy in patients with large B-cell lymphoma, with early NK cell recovery emerging as a key predictor of survival. These findings provide potential future avenues of research for improving patient outcomes and tailoring post-therapy management strategies to mitigate relapse risk. ©2024 American Association for Cancer Research. |
| Keywords: | adult; treatment outcome; aged; middle aged; mortality; immunology; chimeric antigen receptor; natural killer cell; killer cells, natural; lymphoma, large b-cell, diffuse; therapy; adoptive immunotherapy; immunotherapy, adoptive; immune reconstitution; procedures; diffuse large b cell lymphoma; humans; human; male; female; receptors, chimeric antigen |
| Journal Title: | Blood Cancer Discovery |
| Volume: | 6 |
| Issue: | 2 |
| ISSN: | 2643-3230 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2025-03-01 |
| Start Page: | 119 |
| End Page: | 130 |
| Language: | English |
| DOI: | 10.1158/2643-3230.Bcd-24-0163 |
| PUBMED: | 39666878 |
| PROVIDER: | scopus |
| PMCID: | PMC11876948 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Roni Shouval -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work