Allogeneic haematopoietic stem cell transplantation: Individualized stem cell and immune therapy of cancer Journal Article

  


Authors: Jenq, R. R.; van den Brink, M. R. M.
Article Title: Allogeneic haematopoietic stem cell transplantation: Individualized stem cell and immune therapy of cancer
Abstract: The year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and the earliest example of individualized cancer therapy. In this Timeline article we review the history of the development of HSCT and major advances made in the past 50 years. We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies. © 2010 Macmillan Publishers Limited. All rights reserved.
Keywords: transplantation, homologous; single nucleotide polymorphism; review; nonhuman; drug megadose; neoplasms; animals; interleukin 2; cancer immunotherapy; interleukin 21; interleukin 7; history, 21st century; cyclophosphamide; stem cell transplantation; hematopoietic stem cell transplantation; cancer research; cancer therapy; history, 20th century; toll like receptor 4; immunological tolerance; immunotherapy; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; mesenchymal stem cell; safety; proteinase; myeloblastin; graft rejection; immune deficiency; autoimmune disease; interleukin 15; chemokine receptor; hematologic disease; tumor necrosis factor; history of medicine; caspase recruitment domain protein 15; tissue therapy; individualized medicine; 5,10 methylenetetrahydrofolate reductase (fadh2)
Journal Title: Nature Reviews Cancer
Volume: 10
Issue: 3
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2010-03-01
Start Page: 213
End Page: 221
Language: English
DOI: 10.1038/nrc2804
PUBMED: 20168320
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77649181500&partnerID=40&md5=b825af8fa83a39e15c8a80bec63d86ce
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: NRCAC" - "Source: Scopus"
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Robert R Jenq
    107 Jenq
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