Blood stem cell transplantation in older patients Journal Article

Authors: Murphy, W. J.; Artz, A. S.; Champlin, R. E.; Koreth, J.; Longo, D. L.; van den Brink, M. R. M.
Article Title: Blood stem cell transplantation in older patients
Abstract: A serious dichotomy currently exists in hematopoietic stem cell transplantation (HSCT) and cancer research. Cancer is a disease that predominantly affects older people, yet there is a paucity of cancer research addressing the very unique needs of this population. Even basic biologic processes that exist in aging (decline in immune competency, increased sensitivities to therapies, etc.) are only beginning to be understood.Proportionally, the vast majority of cancer preclinical research does not involve the use of aged animals due to expense and time. This seriously hampers realistic extrapolation of preclinical findings to the general population affected by cancer. This report recommends research priorities that can help close the gaps in our understanding of aging as it relates to HSCT and cancer.
Keywords: aged; middle aged; neoplasm; neoplasms; hematopoietic stem cell transplantation; age factors; age; immunology; aging
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 15
Issue: 12
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2009-12-01
Start Page: 1638
End Page: 1639
Language: English
PUBMED: 19911448
PROVIDER: scopus
DOI: 10.1016/j.bbmt.2009.10.014
Notes: --- - "Export Date: 28 June 2012" - "Source: Scopus"
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