Utilization of CAR T cell therapy in pediatric patients Review

  


Authors: Szenes, V.; Curran, K. J.
Review Title: Utilization of CAR T cell therapy in pediatric patients
Abstract: Objective: To provide an overview of chimeric antigen receptor (CAR) T cell therapy for pediatric patients with relapsed or refractory malignancy and the associated toxicities. Data Sources: Research articles, reviews, clinical trial information. Conclusion: The key to the successful application of CAR T cell immunotherapy is (1) identifying patients with malignancies that are eligible for immunotherapy, (2) coordinating T-cell collection, (3) safe infusion of CAR T cells, and (4) managing/preventing toxicities following infusion. Implications for Nursing Practice: As the use of targeted therapy with tumor-specific T cells becomes more prevalent, it is essential that the nursing staff stay abreast of these current therapies. © 2019 Elsevier Inc.
Keywords: neurotoxicity; acute lymphoblastic leukemia; immunotherapy; cytokine release syndrome; car t cell therapy
Journal Title: Seminars in Oncology Nursing
Volume: 35
Issue: 5
ISSN: 0749-2081
Publisher: Elsevier Inc.  
Date Published: 2019-10-01
Start Page: 150929
Language: English
DOI: 10.1016/j.soncn.2019.08.008
PUBMED: 31526551
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072180030&doi=10.1016%2fj.soncn.2019.08.008&partnerID=40&md5=7b3c2415da46de95ae270c585498a7c8
Notes: Source: Scopus
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MSK Authors
  1. Kevin Joseph Curran
    148 Curran
  2. Victoria Zee Szenes
    16 Szenes
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