Targeting RNA and protein turnover in aneuploid cancers Editorial
| Author: | Bakhoum, S. F. |
| Title: | Targeting RNA and protein turnover in aneuploid cancers |
| Abstract: | Aneuploidy, an imbalance in chromosome number, is a hallmark of human cancers with chromosomal instability, and it remains a major therapeutic challenge. In this issue, Ippolito and colleagues identify RNA and protein turnover as targetable therapeutic vulnerabilities in aneuploid cancers. © 2024 American Association for Cancer Research. |
| Keywords: | protein expression; genetics; nonhuman; note; neoplasm; neoplasms; metabolism; dna damage; melanoma; apoptosis; bortezomib; multiple myeloma; gene expression; protein metabolism; protein p53; carcinogenesis; cell heterogeneity; rna; messenger rna; protein synthesis; chromosomal instability; upregulation; oxidative stress; drug therapy; homeostasis; rna processing; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; aneuploidy; molecularly targeted therapy; protein homeostasis; molecular targeted therapy; nonsense mediated mrna decay; chromothripsis; humans; human |
| Journal Title: | Cancer Discovery |
| Volume: | 14 |
| Issue: | 12 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2024-12-01 |
| Start Page: | 2315 |
| End Page: | 2316 |
| Language: | English |
| DOI: | 10.1158/2159-8290.Cd-24-1350 |
| PUBMED: | 39618281 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
