Micronuclei and cancer Review
| Authors: | Di Bona, M.; Bakhoum, S. F. |
| Review Title: | Micronuclei and cancer |
| Abstract: | Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability. Although their association with cancer has been long recognized, only recently have we broadened our understanding of the mechanisms that govern micronuclei formation and their role in tumor progression. In this review, we provide a brief historical account of micronuclei, depict the mechanisms underpinning their creation, and illuminate their capacity to propel tumor evolution through genetic, epigenetic, and transcriptional transformations. We also posit the prospect of leveraging micronuclei as biomarkers and therapeutic targets in chromosomally unstable cancers. SIGNIFICANCE: Micronuclei in chromosomally unstable cancer cells serve as pivotal catalysts for cancer progression, instigating transformative genomic, epigenetic, and transcriptional alterations. This comprehensive review not only synthesizes our present comprehension but also outlines a framework for translating this knowledge into pioneering biomarkers and therapeutics, thereby illuminating novel paths for personalized cancer management. ©2023 American Association for Cancer Research. |
| Keywords: | human cell; cancer growth; biological marker; gene expression; cancer cell; diagnosis; chromosomal instability; tumor growth; drug therapy; therapy; catalyst; micronucleus; human; article; malignant neoplasm |
| Journal Title: | Cancer Discovery |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2024-02-01 |
| Start Page: | 214 |
| End Page: | 226 |
| Language: | English |
| DOI: | 10.1158/2159-8290.Cd-23-1073 |
| PUBMED: | 38197599 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Both authors are considered the corresponding authors -- Source: Scopus |
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