Engineering chromosome rearrangements in cancer Review
| Authors: | Alonso, S.; Dow, L. E. |
| Review Title: | Engineering chromosome rearrangements in cancer |
| Abstract: | The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in model systems. The emergence and refinement of genome editing technologies, such as CRISPR, have significantly expanded our ability to generate and interrogate chromosomal aberrations to better understand the networks that govern cancer growth. Here we review how existing technologies are employed to faithfully model cancerassociated chromosome rearrangements in the laboratory, with the ultimate goal of developing more accurate pre-clinical models of and therapeutic strategies for cancers driven by these genomic events. © 2021. Published by The Company of Biologists Ltd. |
| Keywords: | chromosomal rearrangements; cancer; crispr; fusion oncogenes |
| Journal Title: | Disease Models & Mechanisms |
| Volume: | 14 |
| Issue: | 9 |
| ISSN: | 1754-8403 |
| Publisher: | Company of Biologists |
| Date Published: | 2021-09-01 |
| Start Page: | 049078 |
| Language: | English |
| DOI: | 10.1242/dmm.049078 |
| PUBMED: | 34585724 |
| PROVIDER: | scopus |
| PMCID: | PMC8489016 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work