Somatic engineering of oncogenic chromosomal rearrangements: A perspective Journal Article
| Authors: | Maddalo, D.; Ventura, A. |
| Article Title: | Somatic engineering of oncogenic chromosomal rearrangements: A perspective |
| Abstract: | The ability to engineer specific mutations in mice has proven essential to advancing our understanding of the molecular basis of cancer. Chromosomal rearrangements, a common and clinically relevant class of cancer-causing mutations, have however remained difficult to faithfully recapitulate in vivo. The development of genetic tools for in vivo somatic genome editing has recentlyovercome this limitation and led to the generation of more sophisticated and accurate preclinical models of human cancers. Here, we review the potential applications of these new technologies to the study of tumor biology and discuss their advantages over more conventional strategies, their limitations, and the remaining challenges. © 2016 American Association for Cancer Research. |
| Journal Title: | Cancer Research |
| Volume: | 76 |
| Issue: | 17 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2016-09-01 |
| Start Page: | 4918 |
| End Page: | 4923 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-16-0726 |
| PROVIDER: | scopus |
| PMCID: | PMC5010508 |
| PUBMED: | 27520450 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 October 2016 -- Source: Scopus |
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