APOBEC mutagenesis in cancer development and susceptibility Editorial
| Authors: | Dananberg, A.; Striepen, J.; Rozowsky, J. S.; Petljak, M. |
| Title: | APOBEC mutagenesis in cancer development and susceptibility |
| Abstract: | Simple Summary: APOBEC cytosine deaminases represent potent mutational sources in over 50% of human cancers and are linked to tumor heterogeneity and therapy responses. However, the understanding of the contribution of APOBEC-mediated mutagenesis to cancer susceptibility and malignant transformation is still limited. The authors review the existing evidence for the impact of APOBEC mutagenesis on cancer development and identify gaps in related knowledge that need to be addressed. APOBEC cytosine deaminases are prominent mutators in cancer, mediating mutations in over 50% of cancers. APOBEC mutagenesis has been linked to tumor heterogeneity, persistent cell evolution, and therapy responses. While emerging evidence supports the impact of APOBEC mutagenesis on cancer progression, the understanding of its contribution to cancer susceptibility and malignant transformation is limited. We examine the existing evidence for the role of APOBEC mutagenesis in carcinogenesis on the basis of the reported associations between germline polymorphisms in genes encoding APOBEC enzymes and cancer risk, insights into APOBEC activities from sequencing efforts of both malignant and non-malignant human tissues, and in vivo studies. We discuss key knowledge gaps and highlight possible ways to gain a deeper understanding of the contribution of APOBEC mutagenesis to cancer development. |
| Keywords: | mutation; neoplasms; disease progression; polymorphism, genetic; disease susceptibility |
| Journal Title: | Cancers |
| Volume: | 16 |
| Issue: | 2 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2024-01-02 |
| Start Page: | 374 |
| Language: | English |
| DOI: | 10.3390/cancers16020374 |
| PROVIDER: | EBSCOhost |
| PROVIDER: | cinahl |
| PMCID: | PMC10814203 |
| PUBMED: | 38254863 |
| DOI/URL: | |
| Notes: | Accession Number: 175048100 -- Entry Date: 20240201 -- Revision Date: 20240201 -- Publication Type: Journal Article; pictorial; tables/charts -- Journal Subset: Biomedical; Continental Europe; Europe -- Special Interest: Oncologic Care -- NLM UID: 101526829. -- Source: Cinahl |
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