Molecular origins of APOBEC-associated mutations in cancer Review
| Authors: | Petljak, M.; Maciejowski, J. |
| Review Title: | Molecular origins of APOBEC-associated mutations in cancer |
| Abstract: | The APOBEC family of cytidine deaminases has been proposed to represent a major enzymatic source of mutations in cancer. Here, we summarize available evidence that links APOBEC deaminases to cancer mutagenesis. We also highlight newly identified human cell models of APOBEC mutagenesis, including cancer cell lines with suspected endogenous APOBEC activity and a cell system of telomere crisis-associated mutations. Finally, we draw on recent data to propose potential causes of APOBEC misregulation in cancer, including the instigating factors, the relevant mutator(s), and the mechanisms underlying generation of the genome-dispersed and clustered APOBEC-induced mutations. © 2020 Elsevier B.V. |
| Keywords: | protein expression; unclassified drug; human cell; nonhuman; telomere; gene locus; enzyme activity; mutational analysis; carcinogenesis; virus; mutagenesis; dna polymorphism; retroposon; cancer cell lines; chromothripsis; human; priority journal; article; cancer cell line; kataegis; malignant neoplasm; mutational signature; apolipoprotein b mrna editing enzyme catalytic polypeptide like; apobec mutations; cancer mutagenesis; apobec3a protein; apobec3b protein |
| Journal Title: | DNA Repair |
| Volume: | 94 |
| ISSN: | 1568-7864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-10-01 |
| Start Page: | 102905 |
| Language: | English |
| DOI: | 10.1016/j.dnarep.2020.102905 |
| PROVIDER: | scopus |
| PUBMED: | 32818816 |
| PMCID: | PMC7494591 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2020 -- Source: Scopus |
