Other Targetable Sarcomas Journal Article
| Authors: | Camargo, V. P.; van de Rijn, M.; de Alava, E.; Madoz-Gúrpide, J.; Pilotti, S.; von Mehren, M.; Pedeutour, F.; Maki, R. G.; Rutkowski, P.; Thomas, D. M. |
| Article Title: | Other Targetable Sarcomas |
| Abstract: | Despite complex genetics, aneuploid tumors like dedifferentiated liposarcoma have specific and reproducible chromosomal changes such as amplification of HDM2 and CDK4 that represent potential targets for systemic therapy. In addition, there are cancer cell survival pathways that may not be the target of chromosomal translocations or mutations that are still estimable targets for new systemic therapeutics, be it pathways involved in angiogenesis or apoptosis. In this review, we examine target selection for specific sarcoma subtypes, and demonstrate with a few examples new techniques being used to delineate novel therapeutic inroads for patients with sarcoma. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; protein expression; cancer surgery; unclassified drug; gene mutation; clinical trial; sorafenib; bevacizumab; doxorubicin; sunitinib; drug efficacy; nonhuman; skin toxicity; unspecified side effect; bone metastasis; disease marker; drug targeting; paclitaxel; cancer radiotherapy; antineoplastic agent; protein function; cell proliferation; cell survival; gastrointestinal stromal tumor; imatinib; drug inhibition; gene amplification; cell differentiation; drug discovery; protein tyrosine kinase; angiogenesis; angiosarcoma; neovascularization, pathologic; proteomics; docetaxel; protein tyrosine kinase inhibitor; ewing sarcoma; sarcoma; cancer genetics; cardiotoxicity; pazopanib; cell migration; tanespimycin; chromosome translocation; kaposi sarcoma; taxane derivative; anthracycline derivative; trabectedin; hemangiopericytoma; leiomyosarcoma; solitary fibrous tumor; synovial sarcoma; mitomycin; chordoma; rapamycin; liposarcoma; cyclin dependent kinase 4; protein mdm2; proto-oncogene proteins c-mdm2; adw 742; fumagillol chloroacetylcarbamate; n acetylsarcosylglycylvalyl dextro alloisoleucylthreonylnorvalylisoleucylarginylproline ethylamide; platelet derived growth factor beta receptor; alveolar soft part sarcoma; desmoplastic small round cell tumor; myxosarcoma; cyclin-dependent kinase 4 |
| Journal Title: | Seminars in Oncology |
| Volume: | 36 |
| Issue: | 4 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-08-01 |
| Start Page: | 358 |
| End Page: | 371 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2009.06.008 |
| PUBMED: | 19664496 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: SOLGA" - "Source: Scopus" |
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