Exploiting signaling pathways and immune targets beyond the standard of care for Ewing sarcoma Review
| Authors: | Casey, D. L.; Lin, T. Y.; Cheung, N. K. V. |
| Review Title: | Exploiting signaling pathways and immune targets beyond the standard of care for Ewing sarcoma |
| Abstract: | Ewing sarcoma (ES) family of tumors includes bone and soft tissue tumors that are often characterized by a specific translocation between chromosome 11 and 22, resulting in the EWS-FLI1 fusion gene. With the advent of multi-modality treatment including cytotoxic chemotherapy, surgery, and radiation therapy, the prognosis for patients with ES has substantially improved. However, a therapeutic plateau is now reached for both localized and metastatic disease over the last two decades. Burdened by the toxicity limits associated with the current frontline systemic therapy, there is an urgent need for novel targeted therapeutic strategies. In this review, we discuss the current treatment paradigm of ES, and explore preclinical evidence and emerging treatments directed at tumor signaling pathways and immune targets. Copyright © 2019 Casey, Lin and Cheung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | ewing sarcoma; immunotherapy; targeted therapy; antibodies; pediatric sarcomas |
| Journal Title: | Frontiers in Oncology |
| Volume: | 9 |
| ISSN: | 2234-943X |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2019-06-19 |
| Start Page: | 537 |
| Language: | English |
| DOI: | 10.3389/fonc.2019.00537 |
| PROVIDER: | scopus |
| PMCID: | PMC6593481 |
| PUBMED: | 31275859 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2019 -- Source: Scopus |
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