A novel paradigm between leukocytosis, G-CSF secretion, neutrophil-to-lymphocyte ratio, myeloid-derived suppressor cells, and prognosis in non-small cell lung cancer Journal Article
| Authors: | Tavakkoli, M.; Wilkins, C. R.; Mones, J. V.; Mauro, M. J. |
| Article Title: | A novel paradigm between leukocytosis, G-CSF secretion, neutrophil-to-lymphocyte ratio, myeloid-derived suppressor cells, and prognosis in non-small cell lung cancer |
| Abstract: | Leukocytosis is a common feature of malignancies. While controversial, there appears to be an association between the degree of tumor-related leukocytosis and prognosis. In this paper, we provide evidence supporting an untapped clinical paradigm linking G-CSF secretion to the induction of leukocytosis and expansion of myeloid-derived suppressor cells, providing an explanation for the association between leukocytosis, elevated neutrophil-to-lymphocyte ratios and prognosis in non-small cell lung cancer. Clinically validating this mechanism may identify MDSCs and G-CSF as dynamic markers of early disease progression and therapeutic response, and shed light onto novel therapeutic avenues for the treatment of patients with non-small cell lung cancer. © 2019 Tavakkoli, Wilkins, Mones and Mauro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | leukocytosis; non-small cell lung cancer; granulocyte-colony stimulating factor (g-csf); nlr; biomarker (development); paraneoplastic leukocytosis; myeloid derived suppressor cell (mdsc); neutrophil to lymphocyte ratio (nlr) |
| Journal Title: | Frontiers in Oncology |
| Volume: | 9 |
| ISSN: | 2234-943X |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2019-04-01 |
| Start Page: | 295 |
| Language: | English |
| DOI: | 10.3389/fonc.2019.00295 |
| PROVIDER: | scopus |
| PMCID: | PMC6497733 |
| PUBMED: | 31080780 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2019 -- Source: Scopus |
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