Functional translocation of Broca's area in a low-grade left frontal glioma: Graph theory reveals the novel, adaptive network connectivity Journal Article
| Authors: | Li, Q.; Dong, J. W.; Del Ferraro, G.; Brennan, N. P.; Peck, K. K.; Tabar, V.; Makse, H. A.; Holodny, A. I. |
| Article Title: | Functional translocation of Broca's area in a low-grade left frontal glioma: Graph theory reveals the novel, adaptive network connectivity |
| Abstract: | We describe frontal language reorganization in a 50-60 year-old right-handed patient with a low-grade left frontotemporal insular glioma. Pre-operative fMRI revealed robust activation in the left superior temporal gyrus (Wernicke Area, WA) and in the right inferior frontal gyrus (right anatomical homolog of Broca Area, BA). Intra-operative cortical stimulation of the left inferior frontal gyrus and adjacent cortices elicited no speech deficits, and gross total resection including the expected location of BA resulted in no speech impairment. We employed statistical inference methods to reconstruct the functional brain network and determined how different brain areas connect with one another. We found that the right homolog of the BA in this patient functionally connected to the same areas as the left BA in a typical healthy control. As opposed to the functional connection of the left BA in a healthy brain, the right BA did not connect directly with the left WA, but connected indirectly, mediated by the pre-Supplementary Motor Area and the Middle Frontal Gyrus. This case illustrates that pre-surgical fMRI may be used to identify atypical hemispheric language reorganization in the presence of brain tumor and that network theory opens the possibility for future insight into the neural mechanism underlying the language reorganization. © 2019 Li, Dong, Del Ferraro, Petrovich Brennan, Peck, Tabar, Makse and Holodny. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | glioma; fmri; graph theory; brain tumor surgery; language function reorganization |
| Journal Title: | Frontiers in Neurology |
| Volume: | 10 |
| ISSN: | 1664-2295 |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2019-07-02 |
| Start Page: | 702 |
| Language: | English |
| DOI: | 10.3389/fneur.2019.00702 |
| PROVIDER: | scopus |
| PMCID: | PMC6615260 |
| PUBMED: | 31333562 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 September 2019 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work