Neurocutaneous melanocytosis-associated hydrocephalus: The Memorial Sloan Kettering experience from 2001 to 2022 Journal Article

  


Authors: Rodriguez, S.; DeIeso-Frechette, F.; Umeasor, C.; Alli, C.; Azzi, C.; Haque, S.; Pugh, J. A.; Meeker, N.; Khakoo, Y.
Article Title: Neurocutaneous melanocytosis-associated hydrocephalus: The Memorial Sloan Kettering experience from 2001 to 2022
Abstract: We report two neurocutaneous melanocytosis (NCM) patients who required ventriculoperitoneal shunt placement and subsequently developed intraperitoneal melanoma. These patients with NCM are at an increased risk for developing NRAS-associated melanomas in the central nervous system, which in turn may lead to symptomatic hydrocephalus requiring cerebrospinal fluid diversion. Due to the rarity of NCM, current knowledge on disease progression and appropriate management is limited. Ongoing studies aiming to better understand this condition and inform its clinical management may help to identify risk factors for developing more severe complications. © 2024 Wiley Periodicals LLC.
Keywords: adolescent; child; clinical article; controlled study; human tissue; preschool child; case report; ascites; nuclear magnetic resonance imaging; disease association; ipilimumab; computer assisted tomography; risk factor; high risk patient; disease severity; newborn; recurrent disease; disease exacerbation; brain ventricle peritoneum shunt; neurocutaneous melanocytosis; hydrocephalus; abdominal disease; oncogene n ras; abdominal cancer; paracentesis; melanocytic tumor; ventriculoperitoneal shunt; nivolumab; human; male; female; article; central nervous system melanoma; cns melanoma
Journal Title: Pediatric Blood and Cancer
Volume: 72
Issue: 1
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2025-01-01
Start Page: e31434
Language: English
DOI: 10.1002/pbc.31434
PUBMED: 39502030
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208185812&doi=10.1002%2fpbc.31434&partnerID=40&md5=2453f49014573c69cdd2ced719539a28
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Yasmin Khakoo -- Source: Scopus
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MSK Authors
  1. Yasmin Khakoo
    149 Khakoo
  2. Sofia S Haque
    148 Haque
  3. Scarlett Rodriguez
    3 Rodriguez
  4. Francesca Deieso-Frechette
    1 Deieso-Frechette
  5. Chidobe Umeasor
    1 Umeasor
  6. Christianah Alli
    1 Alli
  7. Caline Azzi
    1 Azzi
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