Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression Journal Article


Authors: Schaff, L. R.; Marghoob, A.; Rosenblum, M. K.; Meyer, R.; Khakoo, Y.
Article Title: Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression
Abstract: Neurocutaneous melanosis (NCM) is the condition of abnormal melanocyte deposition in the leptomeninges and brain parenchyma. Associated with congenital melanocytic nevi, NCM can result in neurologic deficits, hydrocephalus, and rarely, malignant transformation of cells. We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. To our knowledge, this is the first reported case of a patient with known NCM undergoing malignant transformation after anti-TNF therapy for inflammatory bowel disease. © 2019 Wiley Periodicals, Inc.
Keywords: case report; melanocytic nevi; immunodeficiency; neoplasms-malignant; tnf inhibitor
Journal Title: Pediatric Dermatology
Volume: 36
Issue: 4
ISSN: 0736-8046
Publisher: Blackwell Scientific Publications  
Date Published: 2019-07-01
Start Page: 497
End Page: 500
Language: English
DOI: 10.1111/pde.13804
PUBMED: 30868657
PROVIDER: scopus
PMCID: PMC6620153
DOI/URL:
Notes: Source: Scopus
Altmetric Score
MSK Authors
  1. Yasmin Khakoo
    102 Khakoo
  2. Marc Rosenblum
    273 Rosenblum
  3. Ashfaq A Marghoob
    397 Marghoob
  4. Lauren Rhea Schaff
    6 Schaff