Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry Journal Article
| Authors: | Agero, A. L. C.; Benvenuto-Andrade, C.; Dusza, S. W.; Halpern, A. C.; Marghoob, A. A. |
| Article Title: | Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry |
| Abstract: | Background: Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23-30%) of asymptomatic NCM. We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool. Methods: Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status. Results: Of 379 patients with LCMN, 26 reportedly had NCM, with 17 reporting neurologic symptoms. Of 186 patients undergoing MRI, 9 reported abnormal findings without neurologic symptoms (4.8%); 80% had LCMN on the posterior axis, whereas 55% had more than 20 satellite nevi. Limitations: Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification. Conclusion: Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi. © 2005 by the American Academy of Dermatology, Inc. |
| Keywords: | adolescent; adult; child; child, preschool; middle aged; nuclear magnetic resonance imaging; skin neoplasms; internet; risk assessment; questionnaire; registries; melanocytic nevus; melanocytosis; infant; infant, newborn; neurocutaneous syndromes; nevus, pigmented; screening; neurologic disease; neurocutaneous melanocytosis; melanosis |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 53 |
| Issue: | 6 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2005-12-01 |
| Start Page: | 959 |
| End Page: | 965 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2005.07.046 |
| PUBMED: | 16310055 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 37" - "Export Date: 24 October 2012" - "CODEN: JAADD" - "Source: Scopus" |
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