Large congenital melanocytic nevi: Associated risks and management considerations Journal Article
| Authors: | Slutsky, J. B.; Barr, J. M.; Femia, A. N.; Marghoob, A. A. |
| Article Title: | Large congenital melanocytic nevi: Associated risks and management considerations |
| Abstract: | Large congenital melanocytic nevi (LCMN) in neonates can cause considerable concern for parents, family members, and physicians. A detailed understanding of the medical risks, including cutaneous melanoma (CM), extracutaneous melanoma (ECM), and neurocutaneous melanocytosis (NCM), as well as the psychological stress that these lesions can cause in patients, will guide informed management decisions as well as provide comfort to parents. Current data indicate that LCMN greater than 20 cm, and more likely greater than 40 to 60 cm, are the lesions at greatest risk for complications such as CM, ECM, and NCM. Additionally, lesions on the trunk are at greater risk for developing CM, and LCMN in association with numerous satellite nevi are at greatest risk for NCM. Individualized management plans, including clinical observation, magnetic resonance imaging (MRI), and possibly surgery should be based on the risk versus benefit ratio, taking into account the size of the LCMN, its location, the number of satellite nevi, symptoms, and numerous other factors which will be reviewed. This paper will provide a detailed analysis of the risks associated with LCMN, as well as a discussion regarding management and treatment options. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer surgery; review; cancer risk; risk benefit analysis; nuclear magnetic resonance imaging; positron emission tomography; cell proliferation; tumor localization; melanoma; skin pigmentation; dermoepidermal junction; melanocyte; tumor volume; epiluminescence microscopy; central nervous system; melanocytic nevus; melanocytosis; spine; emotion; behavior; seizure; headache; neurologic disease; myelination; neurocutaneous melanocytosis; mental stress; extracutaneous melanoma; skin surgery; social psychology; curettage; clinical observation; scar; low level laser therapy; leptomeninx; subcutaneous tissue; trunk; disease registry; large congenital melanocytic nevus; skin abrasion |
| Journal Title: | Seminars in Cutaneous Medicine and Surgery |
| Volume: | 29 |
| Issue: | 2 |
| ISSN: | 1085-5629 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2010-06-01 |
| Start Page: | 79 |
| End Page: | 84 |
| Language: | English |
| DOI: | 10.1016/j.sder.2010.04.007 |
| PROVIDER: | scopus |
| PUBMED: | 20579596 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: SCMSF" - "Source: Scopus" |
