Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging Review

  


Authors: Boykoff, N.; Grimm, J.
Review Title: Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging
Abstract: Background: Cerenkov luminescence imaging (CLI) is a new emerging technology that can be used for optical imaging of approved radiotracers, both in a preclinical, and even more recently, in a clinical context with rapid imaging times, low costs, and detection in real-time (Grootendorst et al. Clin Transl Imaging 4(5):353–66, 2016); Wang et al. Photonics 9(6):390, 2022). This brief review provides an overview of clinical applications of CLI with a focus on intraoperative margin assessment (IMA) to address shortcomings and provide insight for future work in this application. Methods: A literature review was performed using PubMed using the search words Cerenkov luminescence imaging (CLI), intraoperative margin assessment (IMA), and image-guided surgery. Articles were selected based on title, abstract, content, and application. Results: Original research was summarized to examine advantages and limitations of CLI compared to other modalities for IMA. The characteristics of Cerenkov luminescence (CL) are defined, and results from relevant clinical trials are discussed. Prospects of ongoing clinical trials are reviewed, along with technological advancements related to CLI. Conclusion: CLI is a proven method for molecular imaging and shows feasibility for determining intraoperative margins if future work involves establishing quantitative approaches for attenuation and scattering, depth analysis, and radiation safety for CLI at a larger scale. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. corrected publication 2024.
Keywords: clinical trial; neoplasm; neoplasms; animal; animals; molecular imaging; diagnostic imaging; luminescence; luminescent measurements; intraoperative period; surgery; clinical application; intra-operative; surgery, computer-assisted; cerenkov; cerenkov luminescence imaging; luminescence imaging; image-guided surgery; image guided surgery; computer assisted surgery; procedures; humans; human; emerging technologies; 'current; intraoperative margin assessment
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 51
Issue: 10
ISSN: 1619-7070
Publisher: Springer  
Date Published: 2024-08-01
Start Page: 2931
End Page: 2940
Language: English
DOI: 10.1007/s00259-024-06602-3
PUBMED: 38243119
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182632732&doi=10.1007%2fs00259-024-06602-3&partnerID=40&md5=f7c19be3810ddd4c35e8f90b6e131bdd
Notes: Review -- Erratum issued, see DOI: 10.1007/s00259-024-06832-5 -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF (misspelled as 'P30 CA08748'); MSK corresponding author is Jan Grimm -- Source: Scopus
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MSK Authors
  1. Jan Grimm
    93 Grimm
  2. Natalie Boykoff
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