Cerenkov imaging Journal Article


Authors: Das, S.; Thorek, D. L. J.; Grimm, J.
Editors: Pomper, M. G.; Fisher, P. B.
Article Title: Cerenkov imaging
Title Series: Advances in Cancer Research
Abstract: Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope (18F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.
Keywords: unclassified drug; nonhuman; cancer radiotherapy; positron emission tomography; technetium 99m; nephrotoxicity; fluorescence; molecular imaging; iodine 131; luminescence; tomography; microfluidics; radioactivity; imaging; nanoparticle; quenching; iodine 124; tracer; radioisotope; fluorine 18; single photon emission computer tomography; endoscopy; photon; radiation energy; bioluminescence; copper 64; gallium 68; quantum dot; zirconium 89; zirconium derivative; polarization; fluorescence imaging; image reconstruction; monte carlo method; gelatinase a; clinical; intraoperative; alpha radiation; white light; positron emission; gamma radiation; cerenkov luminescence imaging; light intensity; yttrium 90; actinium 225; light scattering; light absorption; cancer biology; graves disease; beta radiation; oxygen 15; nitrogen 13; gamma camera; radiation physics; arsenic derivative; refraction index; fiberoscope; cerenkov luminescence; human; article; activatable; in vivo light; low-light camera; scifi; smart; arsenic 74; fluorochrome; cerenkov luminescence endoscopy; cerenkov luminescence tomography; threshold energy
Journal Title: Advances in Cancer Research
Volume: 124
ISSN: 0065-230X
Publisher: Academic Press, Elsevier Inc  
Date Published: 2014-01-01
Start Page: 213
End Page: 234
Language: English
DOI: 10.1016/b978-0-12-411638-2.00006-9
PROVIDER: scopus
PUBMED: 25287690
PMCID: PMC4329979
DOI/URL:
Notes: Chapter 6 in "Emerging Applications of Molecular Imaging to Oncology" (ISBN: 978-0-12-411638-2) -- Export Date: 3 November 2014 -- Source: Scopus
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MSK Authors
  1. Jan Grimm
    62 Grimm
  2. Sudeep Das
    4 Das